From therapeutic drug monitoring to model‐informed precision dosing for antibiotics

SG Wicha, AG Märtson, EI Nielsen… - Clinical …, 2021 - Wiley Online Library
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Drug‐resistant tuberculosis: an update on disease burden, diagnosis and treatment

C Lange, D Chesov, J Heyckendorf, CC Leung… - …, 2018 - Wiley Online Library
The emergence of antimicrobial resistance against Mycobacterium tuberculosis, the leading
cause of mortality due to a single microbial pathogen worldwide, represents a growing threat …

Therapeutic drug monitoring in the treatment of tuberculosis: an update

A Alsultan, CA Peloquin - Drugs, 2014 - Springer
Tuberculosis (TB) is the world's second leading infectious killer. Cases of multidrug-resistant
(MDR-TB) and extremely drug-resistant (XDR-TB) have increased globally. Therapeutic …

Therapeutic drug monitoring by dried blood spot: progress to date and future directions

AJ Wilhelm, JCG den Burger, EL Swart - Clinical pharmacokinetics, 2014 - Springer
This article discusses dried blood spot (DBS) sampling in therapeutic drug monitoring
(TDM). The most important advantages of DBS sampling in TDM are the minimally invasive …

Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications

BS Frey, DE Damon… - Mass spectrometry …, 2020 - Wiley Online Library
Recent advancements in the sensitivity of chemical instrumentation have led to increased
interest in the use of microsamples for translational and biomedical research. Paper …

Dried blood spots analysis with mass spectrometry: potentials and pitfalls in therapeutic drug monitoring

MV Antunes, MF Charão, R Linden - Clinical biochemistry, 2016 - Elsevier
Therapeutic drug monitoring (TDM) relays in the availability of specialized laboratory
assays, usually available in reference centers that are not accessible to all patients. In this …

[HTML][HTML] Multidrug-resistant and extensively drug-resistant tuberculosis: a review of current concepts and future challenges

G Günther - Clinical medicine, 2014 - Elsevier
Multidrug-resistant and extensively drug-resistant tuberculosis are recent global health
issues, which makes tuberculosis–after the success of short course treatment during the …

How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?

G Wong, FB Sime, J Lipman, JA Roberts - BMC infectious diseases, 2014 - Springer
High mortality and morbidity rates associated with severe infections in the critically ill
continue to be a significant issue for the healthcare system. In view of the diverse and …

Linezolid-based regimens for multidrug-resistant tuberculosis (TB): a systematic review to establish or revise the current recommended dose for TB treatment

MS Bolhuis, OW Akkerman… - Clinical Infectious …, 2018 - academic.oup.com
Linezolid has been successfully used for treatment of multidrug-resistant tuberculosis (MDR-
TB). However, dose-and duration-related toxicity limit its use. Here, our aim was to search …

Expert consensus statement on therapeutic drug monitoring and individualization of linezolid

B Lin, Y Hu, P Xu, T Xu, C Chen, L He, M Zhou… - Frontiers in Public …, 2022 - frontiersin.org
Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and
individualized treatment have been challenged since its approval. With the in-depth clinical …