Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview

R Castro, I Rivera, HJ Blom, C Jakobs… - Journal of Inherited …, 2006 - Wiley Online Library
Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for
atherosclerosis and vascular disease. Homocysteine is a branch‐point intermediate of …

Vitamin B12 in neurology and ageing; clinical and genetic aspects

A McCaddon - Biochimie, 2013 - Elsevier
The classic neurological and psychiatric features associated with vitamin B12 deficiency
have been well described and are the subject of many excellent review articles. The advent …

[图书][B] Handbook of vitamins

J Zempleni, JW Suttie, JF Gregory III, PJ Stover - 2013 - books.google.com
Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Measurement of Total Vitamin B12 and Holotranscobalamin, Singly and in Combination, in Screening for Metabolic Vitamin B12 Deficiency

JW Miller, MG Garrod, AL Rockwood… - Clinical …, 2006 - academic.oup.com
Background: The standard screening test for vitamin B12 deficiency, measurement of total
plasma vitamin B12, has limitations of sensitivity and specificity. Plasma vitamin B12 bound …

Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor

EV Quadros, JM Sequeira - Biochimie, 2013 - Elsevier
Cellular uptake of cobalamin is facilitated by a receptor-mediated endocytosis process
involving transcobalamin, a plasma protein that binds cobalamin and a cell surface receptor …

Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications

H Zetterberg - Reproductive Biology and Endocrinology, 2004 - Springer
The pathogenesis of human spontaneous abortion involves a complex interaction of several
genetic and environmental factors. The firm association between increased homocysteine …

Transcobalamin II 775G> C polymorphism and indices of vitamin B12 status in healthy older adults

JW Miller, MI Ramos, MG Garrod… - Blood, The Journal …, 2002 - ashpublications.org
Abstract A common polymorphism (775G> C) in the vitamin B12 transport protein,
transcobalamin II (TCII), has been identified in which proline replaces arginine at codon 259 …

Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and Down syndrome?

JL Guéant, RM Guéant-Rodriguez, G Anello, P Bosco… - 2003 - degruyter.com
One-carbon metabolism is under the influence of folate, vitamin B12 and genetic
polymorphisms of methylenetetrahydrofolate reductase (MTHFR 677 C→ T and 1298 A→ …

[图书][B] Handbook of vitamins

RB Rucker, J Zempleni, JW Suttie, DB McCormick - 2007 - taylorfrancis.com
Thoroughly revised and updated, Handbook of Vitamins highlights the recent research in
vitamins and gene expression, vitamin-dependent genes, and vitamin effect on DNA …

Genetic determinants of plasma total homocysteine

H Gellekink, M Den Heijer, SG Heil… - Seminars in vascular …, 2005 - thieme-connect.com
Hyperhomocysteinemia (Hhcy) is an established risk factor for various pathologies including
arterial vascular disease and venous thrombosis, congenital malformations and other …