Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …

Long non-coding RNAs (lncRNAs) are RNA molecules with a transcript length of more than
200 nt and lack a protein-coding ability. They regulate gene expression by interacting with …

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

A significant portion of the human genome encodes genes that transcribe long nonprotein-
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …

Mouse studies have been instrumental in forming our current understanding of early cell-
lineage decisions; however, similar insights into the early human development are severely …

Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …

Although many long noncoding RNAs (lncRNAs) have been identified in human and other
mammalian genomes, there has been limited systematic functional characterization of these …

Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a
multitude of pathways across species, but it remains challenging to understand which of …

The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

Eukaryotic genomes are pervasively transcribed, with tens of thousands of RNAs emanating
from uni-and bi-directional promoters and from active enhancers. In vertebrates, thousands …