Alport syndrome is a genetically and phenotypically heterogeneous disorder of glomerular,
cochlear, and ocular basement membranes resulting from mutations in the collagen IV …

In 2013, we published a set of clinical practice recommendations for the treatment of Alport
syndrome in this journal. We recommended delaying the initiation of angiotensin-converting …

Alport syndrome inevitably leads to end-stage renal disease and there are no therapies
known to improve outcome. Here we determined whether angiotensin-converting enzyme …

Abstract In 1927, Arthur C. Alport first published his description of a triad of symptoms in a
family with hereditary congenital haemorrhagic nephritis, deafness and ocular changes. A …

Laminin (Ln) and collagen are multifunctional glycoproteins that play an important role in
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …

Fibroblast growth factor 23 (FGF23) is secreted primarily by osteocytes and regulates
phosphate and vitamin D metabolism. Elevated levels of FGF23 are clinically associated …

The renin–angiotensin system (RAS) is usually associated with its systemic action on
cardiovascular homoeostasis. However, recent studies suggest that at a local tissue level …

Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that
regulates phosphate and vitamin D metabolism. Recent observational studies in humans …

We present clinical practice recommendations for the treatment of children with Alport
syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a …

Alport syndrome (AS) is a hereditary kidney disease associated with proteinuria, hematuria
and progressive kidney failure. It is characterized by a defective glomerular basement …