Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
PT Nelson, DW Dickson, JQ Trojanowski, CR Jack… - Brain, 2019 - academic.oup.com
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
Imaging the evolution and pathophysiology of Alzheimer disease
W Jagust - Nature Reviews Neuroscience, 2018 - nature.com
Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …
studies of the relationships between the two major proteins deposited in this disease …
Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup
CR Jack Jr, JS Andrews, TG Beach… - Alzheimer's & …, 2024 - Wiley Online Library
Abstract The National Institute on Aging and the Alzheimer's Association convened three
separate work groups in 2011 and single work groups in 2012 and 2018 to create …
separate work groups in 2011 and single work groups in 2012 and 2018 to create …
Discriminative accuracy of [18F] flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders
Importance The positron emission tomography (PET) tracer [18 F] flortaucipir allows in vivo
quantification of paired helical filament tau, a core neuropathological feature of Alzheimer …
quantification of paired helical filament tau, a core neuropathological feature of Alzheimer …
Alzheimer disease
DS Knopman, H Amieva, RC Petersen… - Nature reviews Disease …, 2021 - nature.com
Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …
A computational model of neurodegeneration in Alzheimer's disease
Disruption of mental functions in Alzheimer's disease (AD) and related disorders is
accompanied by selective degeneration of brain regions. These regions comprise large …
accompanied by selective degeneration of brain regions. These regions comprise large …
The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes
CR Jack Jr, HJ Wiste, H Botha, SD Weigand… - Brain, 2019 - academic.oup.com
Large phenotypically diverse research cohorts with both amyloid and tau PET have only
recently come into existence. Our objective was to determine relationships between the …
recently come into existence. Our objective was to determine relationships between the …
Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer's disease brain
Background Mitochondrial dysfunction is a feature of neurodegenerative diseases, including
Alzheimer's disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and …
Alzheimer's disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and …
Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease
Posterior cortical hypometabolism measured with 18F-fluorodeoxyglucose (FDG)-PET is a
well-known marker of Alzheimer's disease-related neurodegeneration, but its associations …
well-known marker of Alzheimer's disease-related neurodegeneration, but its associations …
18F-FDG PET imaging in neurodegenerative dementing disorders: insights into subtype classification, emerging disease categories, and mixed dementia with …
S Minoshima, D Cross, T Thientunyakit… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Since the invention of 18 F-FDG as a neurochemical tracer in the 1970s, 18 F-FDG PET has
been used extensively for dementia research and clinical applications. FDG, a glucose …
been used extensively for dementia research and clinical applications. FDG, a glucose …