Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches
JF Poulin, Z Gaertner, OA Moreno-Ramos… - Trends in …, 2020 - cell.com
Dysfunctional dopamine (DA) signaling has been associated with a broad spectrum of
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …
Unraveling the dynamics of dopamine release and its actions on target cells
T Sippy, NX Tritsch - Trends in neurosciences, 2023 - cell.com
The neuromodulator dopamine (DA) is essential for regulating learning, motivation, and
movement. Despite its importance, however, the mechanisms by which DA influences the …
movement. Despite its importance, however, the mechanisms by which DA influences the …
[HTML][HTML] VTA glutamate neuron activity drives positive reinforcement absent dopamine co-release
Like ventral tegmental area (VTA) dopamine (DA) neurons, VTA glutamate neuron activity
can support positive reinforcement. However, a subset of VTA neurons co-release DA and …
can support positive reinforcement. However, a subset of VTA neurons co-release DA and …
[HTML][HTML] Comprehensive dual-and triple-feature intersectional single-vector delivery of diverse functional payloads to cells of behaving mammals
The resolution and dimensionality with which biologists can characterize cell types have
expanded dramatically in recent years, and intersectional consideration of such features (eg …
expanded dramatically in recent years, and intersectional consideration of such features (eg …
[HTML][HTML] Proceedings of the eighth annual deep brain stimulation think tank: advances in optogenetics, ethical issues affecting DBS research, neuromodulatory …
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to
address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters …
address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters …
[HTML][HTML] Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner
Striatal activity is dynamically modulated by acetylcholine and dopamine, both of which are
essential for basal ganglia function. Synchronized pauses in the activity of striatal …
essential for basal ganglia function. Synchronized pauses in the activity of striatal …
Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking
AL Collins, BT Saunders - Journal of neuroscience research, 2020 - Wiley Online Library
The striatal dopamine system has long been studied in the context of reward learning,
motivation, and movement. Given the prominent role dopamine plays in a variety of adaptive …
motivation, and movement. Given the prominent role dopamine plays in a variety of adaptive …
[HTML][HTML] New insights into cholinergic neuron diversity
NY Ahmed, R Knowles, N Dehorter - Frontiers in molecular …, 2019 - frontiersin.org
Cholinergic neurons comprise a small population of cells in the striatum but have
fundamental roles in fine tuning brain function, and in the etiology of neurological and …
fundamental roles in fine tuning brain function, and in the etiology of neurological and …
[HTML][HTML] Molecular heterogeneity in the substantia nigra: A roadmap for understanding PD motor pathophysiology
As the ability to capture single-cell expression profiles has grown in recent years,
neuroscientists studying a wide gamut of brain regions have discovered remarkable …
neuroscientists studying a wide gamut of brain regions have discovered remarkable …
[HTML][HTML] In vivo functional diversity of midbrain dopamine neurons within identified axonal projections
Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from
differences in intrinsic properties and connectivity to selective task engagement in behaving …
differences in intrinsic properties and connectivity to selective task engagement in behaving …