The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine
S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
Biased allosteric modulators: new frontiers in GPCR drug discovery
G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in the
genome and the most successful family of targets of FDA-approved drugs. New frontiers in …
genome and the most successful family of targets of FDA-approved drugs. New frontiers in …
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a
major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the …
major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the …
Biased receptor signaling in drug discovery
T Kenakin - Pharmacological reviews, 2019 - ASPET
A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …
active states that go on to interact with cellular signaling proteins to form a range of different …
Amylin: pharmacology, physiology, and clinical potential
Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …
systems. Here, we review the literature in rodents and in humans on amylin research since …
The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR review 1
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase‐activating polypeptide
(PACAP) are members of a superfamily of structurally related peptide hormones that …
(PACAP) are members of a superfamily of structurally related peptide hormones that …
Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors
KL Becker, ES Nylen, JC White, B Muller… - The Journal of …, 2004 - academic.oup.com
Calcitonin (CT) is a hormone that received its name because of its secretion in response to
induced hypercalcemia and its hypocalcemic effect (1). It was shown to originate from the …
induced hypercalcemia and its hypocalcemic effect (1). It was shown to originate from the …
Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors
The concept of biased agonism has recently come to the fore with the realization that seven-
transmembrane receptors (7TMRs, also known as G protein–coupled receptors, or GPCRs) …
transmembrane receptors (7TMRs, also known as G protein–coupled receptors, or GPCRs) …
Vascular actions of calcitonin gene-related peptide and adrenomedullin
SD Brain, AD Grant - Physiological reviews, 2004 - journals.physiology.org
This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …