Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
[HTML][HTML] Isothermal amplified detection of DNA and RNA
This review highlights various methods that can be used for a sensitive detection of nucleic
acids without using thermal cycling procedures, as is done in PCR or LCR. Topics included …
acids without using thermal cycling procedures, as is done in PCR or LCR. Topics included …
The good, the bad, and the ugly–controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy
S Callaghan, MO Senge - Photochemical & photobiological sciences, 2018 - pubs.rsc.org
Singlet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable,
suffers from poor selectivity and has fast decomposition rates in biological media. Across the …
suffers from poor selectivity and has fast decomposition rates in biological media. Across the …
Metal complex catalysis in living biological systems
PK Sasmal, CN Streu, E Meggers - Chemical Communications, 2013 - pubs.rsc.org
This feature article discusses synthetic metal complexes that are capable of catalyzing
chemical transformations in living organisms. Photodynamic therapy exemplifies what is …
chemical transformations in living organisms. Photodynamic therapy exemplifies what is …
Reactions templated by nucleic acids: more ways to translate oligonucleotide‐based instructions into emerging function
K Gorska, N Winssinger - Angewandte Chemie International …, 2013 - Wiley Online Library
The programmability of oligonucleotide recognition offers an attractive platform to direct the
assembly of reactive partners that can engage in chemical reactions. Recently, significant …
assembly of reactive partners that can engage in chemical reactions. Recently, significant …
Efficient two-electron reduction of dioxygen to hydrogen peroxide with one-electron reductants with a small overpotential catalyzed by a cobalt chlorin complex
A cobalt chlorin complex (CoII (Ch)) efficiently and selectively catalyzed two-electron
reduction of dioxygen (O2) by one-electron reductants (ferrocene derivatives) to produce …
reduction of dioxygen (O2) by one-electron reductants (ferrocene derivatives) to produce …
Polymersome popping by light‐induced osmotic shock under temporal, spatial, and spectral control
A Peyret, E Ibarboure, A Tron, L Beauté… - Angewandte Chemie …, 2017 - Wiley Online Library
The light‐triggered, programmable rupture of cell‐sized vesicles is described, with particular
emphasis on self‐assembled polymersome capsules. The mechanism involves a hypotonic …
emphasis on self‐assembled polymersome capsules. The mechanism involves a hypotonic …
Detection of miRNA in Live Cells by Using Templated RuII‐Catalyzed Unmasking of a Fluorophore
KK Sadhu, N Winssinger - Chemistry–A European Journal, 2013 - Wiley Online Library
Reactions templated by cellular nucleic acids are attractive for nucleic acid sensing or
responsive systems. Herein we report the use of a photocatalyzed reductive cleavage of an …
responsive systems. Herein we report the use of a photocatalyzed reductive cleavage of an …
Nucleic acid templated reactions for chemical biology
M Di Pisa, O Seitz - ChemMedChem, 2017 - Wiley Online Library
Nucleic acid directed bioorthogonal reactions offer the fascinating opportunity to unveil and
redirect a plethora of intracellular mechanisms. Nano‐to picomolar amounts of specific RNA …
redirect a plethora of intracellular mechanisms. Nano‐to picomolar amounts of specific RNA …
Endoperoxides revealed as origin of the toxicity of graphene oxide
H Pieper, S Chercheja, S Eigler… - Angewandte Chemie …, 2016 - Wiley Online Library
Potential biomedicinal applications of graphene oxide (GO), for example, as a carrier of
biomolecules or a reagent for photothermal therapy and biosensing, are limited by its …
biomolecules or a reagent for photothermal therapy and biosensing, are limited by its …