Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …

The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …

In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …

In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …

Ribonucleosides inhibit human immunodeficiency virus type 1 (HIV-1) replication by
mechanisms that have not been fully elucidated. Here, we report the antiviral mechanism for …

Picornaviridae is one of the largest viral families and is composed of 14 genera, six of which
include human pathogens. The best known picornaviruses are enteroviruses (including …

Enteroviruses (EVs) are common human pathogens that are associated with numerous
disease symptoms in many organ systems of the body. Although EV infections commonly …

Resistance of viruses to mutagenic agents is an important problem for the development of
lethal mutagenesis as an antiviral strategy. Previous studies with RNA viruses have …

Abstract Enterovirus 71 (EV-71) is the main etiological agent of hand, foot and mouth
disease (HFMD). Recent EV-71 outbreaks in Asia-Pacific were not limited to mild HFMD, but …

ABSTRACT Enterovirus 71 (EV71) has emerged as an important virulent neurotropic
enterovirus in young children. DTriP-22 (4 {4-[(2-bromo-phenyl)-(3-methyl-thiophen-2-yl) …