Abstract Anthracyclines Doxorubicin, Epirubicin, Daunorubicin and Idarubicin are used to
treat a variety of tumor types in the clinics, either alone or, most often, in combination …

Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene
expression by remodeling chromatin structure. An imbalance of histone acetylation caused …

Most human cancers develop from stem and progenitor cell populations through the
sequential accumulation of various genetic and epigenetic alterations. Cancer stem cells …

Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in
childhood. Despite intense efforts to develop a successful treatment, current available …

Neuroblastoma is a challenging childhood malignancy, with a very high percentage of
patients relapsing following acquisition of drug resistance, thereby necessitating the …

Cancer stem-like cell (CSC) model has been established to investigate the underlying
mechanisms of tumor initiation and progression. The imbalance between acetylation and …

The development of local recurrence and metastatic disease, most probably attributable to
the intrinsic or acquired resistance of tumor cells to standard therapy, still constitute the …

Cancer stem cells (CSCs) are rare sub-population in tumor mass with self-renewal and
differentiation abilities; CSCs are considered as the main cells which are responsible for …

Chemotherapy and targeted therapy can significantly improve survival rates in cancer, but
multiple drug resistance (MDR) limits the efficacy of these approaches. Understanding the …

In the pediatric population, brain tumors represent the most commonly diagnosed solid
neoplasms and the leading cause of cancer-related deaths globally. They include low-grade …