Preterm birth contributes significantly to neonatal mortality and morbidity. Despite its global
significance, there has only been limited progress in preventing preterm birth. Spontaneous …

Preterm birth (PTB) complications are the leading cause of long-term morbidity and mortality
in children. By using whole blood samples, we integrated whole-genome sequencing …

The early developmental phase is of critical importance for human health and disease later
in life. To decipher the molecular mechanisms at play, current biomedical research is …

Preterm birth is attributed to neonatal morbidity as well as cognitive and physiological
challenges. We have previously identified significant differences in mRNA expression in …

Currently, there is no comprehensive framework to evaluate the evolutionary forces acting
on genomic regions associated with human complex traits and contextualize the relationship …

Preterm birth, or the delivery of an infant prior to 37 weeks of gestation, is a significant cause
of infant morbidity and mortality. In the last decade, the advent and continued development …

The placenta is essential for a healthy pregnancy, and placental pathology can endanger
both maternal and fetal health. Placental function is affected by dynamic, complex, and …

Background The integration of high-quality, genome-wide analyses offers a robust approach
to elucidating genetic factors involved in complex human diseases. Even though several …

Human pregnancy requires the coordinated function of multiple tissues in both mother and
fetus and has evolved in concert with major human adaptations. As a result, pregnancy …

Preterm birth, defined as a birth before 37 weeks of gestation, is prevalent and leads to
significant morbidity and mortality worldwide. The pathogenesis of preterm birth, and more …