Galectin-3: one molecule for an alphabet of diseases, from A to Z

S Sciacchitano, L Lavra, A Morgante, A Ulivieri… - International journal of …, 2018 - mdpi.com
Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix
interactions, growth, proliferation, differentiation, and inflammation. It is not surprising …

Protein glycosylation in cancer

SR Stowell, T Ju, RD Cummings - Annual Review of Pathology …, 2015 - annualreviews.org
Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

T Kouo, L Huang, AB Pucsek, M Cao, S Solt… - Cancer immunology …, 2015 - AACR
Abstract Galectin-3 is a 31-kDa lectin that modulates T-cell responses through several
mechanisms, including apoptosis, T-cell receptor (TCR) cross-linking, and TCR …

Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance

P Li, S Liu, M Lu, G Bandyopadhyay, D Oh, T Imamura… - Cell, 2016 - cell.com
In obesity, macrophages and other immune cells accumulate in insulin target tissues,
promoting a chronic inflammatory state and insulin resistance. Galectin-3 (Gal3), a lectin …

Pathogenesis, treatment, and prevention of pneumococcal pneumonia

T van der Poll, SM Opal - The Lancet, 2009 - thelancet.com
Pneumococcus remains the most common cause of community-acquired pneumonia
worldwide. Streptococcus pneumoniae is well adapted to people, and is a frequent …

The many roles of galectin‐3, a multifaceted molecule, in innate immune responses against pathogens

L Díaz-Alvarez, E Ortega - Mediators of inflammation, 2017 - Wiley Online Library
Galectins are a group of evolutionarily conserved proteins with the ability to bind β‐
galactosides through characteristic carbohydrate‐recognition domains (CRD). Galectin‐3 is …

Galectin-3: an open-ended story

J Dumic, S Dabelic, M Flögel - … et Biophysica Acta (BBA)-General Subjects, 2006 - Elsevier
Galectins, an ancient lectin family, are characterized by specific binding of β-galactosides
through evolutionary conserved sequence elements of carbohydrate-recognition domain …

Galectins: structure, function and therapeutic potential

RY Yang, GA Rabinovich, FT Liu - Expert reviews in molecular …, 2008 - cambridge.org
Galectins are a family of animal lectins that bind β-galactosides. Outside the cell, galectins
bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular …

Hyperinflammation and fibrosis in severe COVID-19 patients: galectin-3, a target molecule to consider

J Garcia-Revilla, T Deierborg, JL Venero… - Frontiers in …, 2020 - frontiersin.org
COVID-19 disease have become so far the most important sanitary crisis in the XXI century.
In light of the events, any clinical resource should be considered to alleviate this crisis …

The regulation of inflammation by galectin‐3

NC Henderson, T Sethi - Immunological reviews, 2009 - Wiley Online Library
Galectin‐3 is a β‐galactoside‐binding animal lectin of appro‐ximately 30 kDa and is
evolutionarily highly conserved. Galectin‐3 is promiscuous, its localization within the tissue …