The development of rapid, selective, and sensitive fluorescent sensors is essential for
visualizing and quantifying biological molecules and processes in vitro, ex vitro, and in vivo …

Introduction The concept of click chemistry was introduced in 2001 as an effective, efficient,
and sustainable approach to making functional groups harnessing the thermodynamic …

High‐throughput synthesis and screening of chemical libraries play pivotal roles in drug
discovery. Click chemistry has emerged as a powerful strategy for constructing highly …

We present the synthesis of 1, 1‐bis (fluorosulfonyl)‐2‐(pyridin‐1‐ium‐1‐yl) ethan‐1‐ide, a
bench‐stable precursor to ethene‐1, 1‐disulfonyl difluoride (EDSF). The novel SuFEx …

Accelerated SuFEx Click Chemistry (ASCC) is a powerful method for coupling aryl and alkyl
alcohols with SuFEx-compatible functional groups. With its hallmark favorable kinetics and …

Phosphorus fluoride exchange (PFEx) is a catalytic click reaction that involves exchanging
high oxidation state P–F bonds with alcohol and amine nucleophiles, reliably yielding P–O …

The control of (bio) chemical processes is fundamental to achieving desired outcomes. In
synthetic processes, inadequate selectivity and stability of reagents can hamper their …

We present the synthesis of 16 unprecedented sulfonyl fluoride functionalized 2-
aminothiazoles in good to excellent yields. The transformation is simple to perform, tolerant …