The abuse of illicit psychostimulants such as cocaine and methamphetamine continues to
pose significant health and societal challenges. Despite considerable efforts to develop …

This narrative review explores the efficacy and tolerability of third-generation antipsychotics
(TGAs)—aripiprazole, cariprazine, brexpiprazole, and lurasidone—for the management of …

The non-medical use of opioids has become a national crisis in the USA. Developing non-
opioid pharmacotherapies for controlling this opioid epidemic is urgent. Dopamine D3 …

Over three decades of evidence indicate that dopamine (DA) D3 receptors (D3R) are
involved in the control of drug-seeking behavior and may play an important role in the …

The crystal structure of the dopamine D3 receptor (D3R) in complex with eticlopride inspired
the design of bitopic ligands that explored (1) N-alkylation of the eticlopride's pyrrolidine …

Cocaine addiction is a significant medical and public concern. Despite decades of research
effort, development of pharmacotherapy for cocaine use disorder remains largely …

Recent studies suggest that dopamine D3 receptors (D3R) may be a therapeutic target for
opioid use disorders (OUD). This study examined the effects of the D3R partial agonist (±) …

Ghrelin, an orexigenic hormone, has emerged as a critical biological substrate implicated in
drug reward. However, the response of the ghrelin system to opioid-motivated behaviors …

A new generation of dual-target μ opioid receptor (MOR) agonist/dopamine D3 receptor
(D3R) antagonist/partial agonists with optimized physicochemical properties was designed …

Opioid use disorder is a worldwide societal problem and public health burden. Strategies for
treating opioid use disorder can be divided into those that target the opioid receptor system …