[HTML][HTML] Biocatalysis

EL Bell, W Finnigan, SP France, AP Green… - Nature Reviews …, 2021 - nature.com
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Advances in ultrahigh-throughput screening for directed enzyme evolution

U Markel, KD Essani, V Besirlioglu, J Schiffels… - Chemical Society …, 2020 - pubs.rsc.org
Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …

Transaminases for industrial biocatalysis: novel enzyme discovery

SA Kelly, S Mix, TS Moody, BF Gilmore - Applied microbiology and …, 2020 - Springer
Transaminases (TAms) are important enzymes for the production of chiral amines for the
pharmaceutical and fine chemical industries. Novel TAms for use in these industries have …

A plurizyme with transaminase and hydrolase activity catalyzes cascade reactions

S Roda, L Fernandez‐Lopez, M Benedens… - Angewandte …, 2022 - Wiley Online Library
Engineering dual‐function single polypeptide catalysts with two abiotic or biotic catalytic
entities (or combinations of both) supporting cascade reactions is becoming an important …

Enzyme adaptation to habitat thermal legacy shapes the thermal plasticity of marine microbiomes

R Marasco, M Fusi, C Coscolín, A Barozzi… - Nature …, 2023 - nature.com
Microbial communities respond to temperature with physiological adaptation and
compositional turnover. Whether thermal selection of enzymes explains marine microbiome …

Synthesis of 12-aminododecenoic acid by coupling transaminase to oxylipin pathway enzymes

A Coenen, M Ferrer, KE Jaeger, U Schörken - Applied Microbiology and …, 2023 - Springer
Biobased polymers derived from plant oils are sustainable alternatives to petro based
polymers. In recent years, multienzyme cascades have been developed for the synthesis of …

Production of l-Theanine by Escherichia coli in the Absence of Supplemental Ethylamine

R Hagihara, S Ohno, M Hayashi… - Applied and …, 2021 - Am Soc Microbiol
ABSTRACT l-Theanine is a nonproteinogenic amino acid present almost exclusively in tea
plants and is beneficial for human health. For industrial production, l-theanine is …

Metabolic engineering of Pseudomonas putida for production of vanillylamine from lignin‐derived substrates

JHC Manfrão‐Netto, F Lund… - Microbial …, 2021 - Wiley Online Library
Whole‐cell bioconversion of technical lignins using Pseudomonas putida strains
overexpressing amine transaminases (ATAs) has the potential to become an eco‐efficient …

Genome mining and characterisation of a novel transaminase with remote stereoselectivity

DP Gavin, FJ Reen, J Rocha-Martin, I Abreu-Castilla… - Scientific reports, 2019 - nature.com
Microbial enzymes from pristine niches can potentially deliver disruptive opportunities in
synthetic routes to Active Pharmaceutical Ingredients and intermediates in the …

ω-Transaminase-Mediated Asymmetric Synthesis of (S)-1-(4-Trifluoromethylphenyl)Ethylamine

CJC Rodrigues, M Ferrer, CCCR de Carvalho - Catalysts, 2021 - mdpi.com
The pivotal role played by ω-transaminases (ω-TAs) in the synthesis of chiral amines used
as building blocks for drugs and pharmaceuticals is widely recognized. However, chiral …