Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …

Objective: To update the 1994 practice parameter for the diagnosis of dementia in the
elderly. Background: The AAN previously published a practice parameter on dementia in …

Importance Typical cognitive aging may be defined as age-associated changes in cognitive
performance in individuals who remain free of dementia. Ideally, the full adult age spectrum …

Background: The cognitive continuum in the elderly population can be conceptually divided
into those who are functioning normally (control subjects), those with a mild cognitive …

Objective: To correlate different methods of measuring rates of brain atrophy from serial MRI
with corresponding clinical change in normal elderly subjects, patients with mild cognitive …

The cortical anatomy of 6 patients with semantic dementia (the temporal lobe variant of
frontotemporal dementia) was contrasted with that of a group of age‐matched normal …

Objective: A history of depression has been linked to an increased dementia risk. This risk
may be particularly high in recurrent depression due to repeated brain insult. We …

Ventricular enlargement may be an objective and sensitive measure of neuropathological
change associated with mild cognitive impairment (MCI) and Alzheimer's disease (AD) …

The ε4 allele of the apolipoprotein E (APOE) gene is a known risk factor for Alzheimer's
disease and may also affect cognitive performance in normal aging. Evidence of the …

The authors describe the development of a four-dimensional atlas and reference system that
includes both macroscopic and microscopic information on structure and function of the …