Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …

Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

Mitochondria serves a primary role in energy maintenance but also function to govern levels
of mitochondria-derived reactive oxygen species (mROS). ROS have long been established …

The survival of a cell depends on its ability to meet its energy requirements. We
hypothesized that the mitochondrial reserve respiratory capacity (RRC) of a cell is a critical …

Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of
reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological …

The antitumor agent lonidamine (LND; 1-(2, 4-dichlorobenzyl)-1H-indazole-3-carboxylic
acid) is known to interfere with energy-yielding processes in cancer cells. However, the …

Glioblastomas (GBM) are some bad prognosis brain tumors despite a conventional
treatment associating surgical resection and subsequent radio-chemotherapy. Among these …

Mitochondria use hydrogen peroxide (H 2 O 2) as a mitokine for cell communication. H 2 O 2
output for signaling depends on its rate of production and degradation, both of which are …

When cellular organelles communicate bad things can happen. Recent findings uncovered
that the junction between the endoplasmic reticulum (ER) and the mitochondria holds a …