Recent progress in the discovery of antifungal agents targeting the cell wall

W Liu, L Yuan, S Wang - Journal of medicinal chemistry, 2020 - ACS Publications
Due to the limit of available treatments and the emergence of drug resistance in the clinic,
invasive fungal infections are an intractable problem with high morbidity and mortality. The …

Recent progress on anti-Candida natural products

SUN Fu-Juan, LI Min, GU Liang, W Ming-Ling… - Chinese Journal of …, 2021 - Elsevier
Candida is an intractable life-threatening pathogen. Candida infection is extremely difficult to
eradicate, and thus is the major cause of morbidity and mortality in immunocompromised …

Antifungal activity and mode of action of thymol and its synergism with nystatin against Candida species involved with infections in the oral cavity: an in vitro study

RD De Castro, TMPA de Souza, LMD Bezerra… - … and alternative medicine, 2015 - Springer
Background Limitations of antifungal agents used in the treatment of oral candidiasis, as the
development of resistant strains, are known by the scientific community. In this context, the …

[HTML][HTML] Evaluation of antifungal activity and mechanism of action of citral against Candida albicans

MCA Leite, AP de Brito Bezerra… - Evidence-based …, 2014 - ncbi.nlm.nih.gov
Candida albicans is a yeast that commensally inhabits the human body and can cause
opportunistic or pathogenic infections. Objective. To investigate the antifungal activity of …

Coriandrum sativum L. (Coriander) Essential Oil: Antifungal Activity and Mode of Action on Candida spp., and Molecular Targets Affected in Human Whole-Genome …

IA Freires, RM Murata, VF Furletti, A Sartoratto… - PLoS …, 2014 - journals.plos.org
Oral candidiasis is an opportunistic fungal infection of the oral cavity with increasingly
worldwide prevalence and incidence rates. Novel specifically-targeted strategies to manage …

Antifungal activity, mode of action and anti-biofilm effects of Laurus nobilis Linnaeus essential oil against Candida spp.

LR Peixoto, PL Rosalen, GLS Ferreira, IA Freires… - Archives of oral …, 2017 - Elsevier
Objective The present study demonstrated the antifungal potential of the chemically
characterized essential oil (EO) of Laurus nobilis L.(bay laurel) against Candida spp. biofilm …

Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis

FO Pereira, JM Mendes, IO Lima, KSL Mota… - Pharmaceutical …, 2015 - Taylor & Francis
Context: Trichophyton rubrum is the most common fungus causing chronic dermatophytosis
in humans. Antifungal activity of promising agents is of great interest. Geraniol and citronellol …

Design, synthesis, mechanistic studies and in silico ADME predictions of benzimidazole derivatives as novel antifungal agents

MM Morcoss, MN El Shimaa, RA Ibrahem… - Bioorganic …, 2020 - Elsevier
Herein, novel three series of benzimidazole scaffold bearing hydrazone, 1, 2, 4-triazole and
1, 3, 4-oxadiazole moieties 1-3, 4a-j, 6a-c and 7 derivatives were designed, synthesized and …

Antifungal Activity of Thymus vulgaris L. Essential Oil and Its Constituent Phytochemicals against Rhizopus oryzae: Interaction with Ergosterol

KSL Mota, FO Pereira, WA De Oliveira, IO Lima… - Molecules, 2012 - mdpi.com
Mucormycoses are emerging infections that have high rates of morbidity and mortality. They
show high resistance to antifungal agents, and there is a limited therapeutic arsenal …

[HTML][HTML] Antibacterial and antifungal activities of phenolic compound-enriched ethyl acetate fraction from Cochlospermum regium (mart. Et. Schr.) Pilger roots …

RS Carvalho, CA Carollo, JC De Magalhães… - South African Journal of …, 2018 - Elsevier
Cochlospermum regium is a shrub used in folk medicine to treat infection diseases.
However, limited information are available regarding the antimicrobial mechanism of action …