Chronic diseases confer tissue and organ damage that reduce quality of life and are largely
refractory to therapy. Although stem cells hold promise for treating degenerative diseases …

Inflammatory bowel disease (IBD) is a multifactorial disease. A breach in the mucosal
barrier, otherwise known as “leaky gut,” is alleged to promote mucosal inflammation by …

Patients with major depressive disorder have elevated peripheral inflammation; the degree
of this increase correlates with the severity of the disorder. Chronic psychological stress …

Activation of NLRP3 inflammasomes is crucial in the pathological process of Ulcerative
colitis (UC), which could be negatively regulated by PINK1/Parkin-driven mitophagy …

Intestinal epithelial barrier dysfunction with dysbiosis of gut microbiota contributes to the
occurrence and acceleration of colitis. This study aimed to evaluate the effect of flaxseed …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is frequently
mutated or overexpressed in a large number of tumors such as carcinomas or glioblastoma …

EGFR signaling regulates macrophage function, but its role in bacterial infection has not
been investigated. Here, we assessed the role of macrophage EGFR signaling during …

Inflammatory bowel disease (IBD) is an idiopathic inflammatory bowel disease. Modulation
of gut microbiota with dietary and nutritional targets is a feasible strategy for the prevention …

Efficient clearance of pro-inflammatory macrophages from tissues after resolution of a
challenge is critical to prevent prolonged inflammation. Defects in clearance can contribute …

Tumor necrosis factor-α (TNFα) has emerged as a pivotal effector critically correlated with
disease severity in acute lung injury (ALI). Because both the excessive activation of …