Brain-immune interactions in perinatal hypoxic-ischemic brain injury
Perinatal hypoxia-ischemia remains the primary cause of acute neonatal brain injury,
leading to a high mortality rate and long-term neurological deficits, such as behavioral …
leading to a high mortality rate and long-term neurological deficits, such as behavioral …
Stem cell therapy for neonatal hypoxic-ischemic encephalopathy: a systematic review of preclinical studies
I Serrenho, M Rosado, A Dinis, C M. Cardoso… - International Journal of …, 2021 - mdpi.com
Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and
morbidity in the perinatal period. This condition results from a period of ischemia and …
morbidity in the perinatal period. This condition results from a period of ischemia and …
FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho
L Ye, X Wang, C Cai, S Zeng, J Bai, K Guo, M Fang… - Experimental …, 2019 - Elsevier
Perinatal asphyxia often results in neonatal cerebral hypoxia-ischemia (HI), which is
associated with high mortality and severe long-term neurological deficits in newborns …
associated with high mortality and severe long-term neurological deficits in newborns …
Stem cell therapy for preventing neonatal diseases in the 21st century: current understanding and challenges
CR Nitkin, J Rajasingh, C Pisano, GE Besner… - Pediatric …, 2020 - nature.com
Diseases of the preterm newborn such as bronchopulmonary dysplasia, necrotizing
enterocolitis, cerebral palsy, and hypoxic-ischemic encephalopathy continue to be major …
enterocolitis, cerebral palsy, and hypoxic-ischemic encephalopathy continue to be major …
Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal …
Perinatal hypoxic ischemic encephalopathy (HIE) results in serious neurological dysfunction
and mortality. Clinical trials of multilineage-differentiating stress enduring cells (Muse cells) …
and mortality. Clinical trials of multilineage-differentiating stress enduring cells (Muse cells) …
Factors influencing the efficacy of umbilical cord blood-derived cell therapy for perinatal brain injury
Introduction We have previously described preclinical literature which supports umbilical
cord blood-derived cell (UCBC) therapy as an efficacious treatment for perinatal brain injury …
cord blood-derived cell (UCBC) therapy as an efficacious treatment for perinatal brain injury …
Systemic administration of clinical-grade multilineage-differentiating stress-enduring cells ameliorates hypoxic–ischemic brain injury in neonatal rats
Multilineage-differentiating stress-enduring (Muse) cells are endogenous reparative
pluripotent stem cells present in the bone marrow, peripheral blood, and organ connective …
pluripotent stem cells present in the bone marrow, peripheral blood, and organ connective …
Intravenous administration of bone marrow-derived mesenchymal stem cell, but not adipose tissue-derived stem cell, ameliorated the neonatal hypoxic-ischemic brain …
Y Sugiyama, Y Sato, Y Kitase, T Suzuki… - Frontiers in …, 2018 - frontiersin.org
Perinatal hypoxic-ischemic (HI) brain injury occurs in 1 in 1,000 live births and remains the
main cause of neurological disability and death in term infants. Cytotherapy has recently …
main cause of neurological disability and death in term infants. Cytotherapy has recently …
Safety and tolerability of a multilineage-differentiating stress-enduring cell-based product in neonatal hypoxic-ischaemic encephalopathy with therapeutic hypothermia …
N Matsuyama, S Shimizu, K Ueda, T Suzuki… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Neonatal hypoxic-ischaemic encephalopathy (HIE) is an important illness
associated with death or cerebral palsy. This study aims to assess the safety and tolerability …
associated with death or cerebral palsy. This study aims to assess the safety and tolerability …
Umbilical cord blood stem cell therapy in premature brain injury: Opportunities and challenges
X Peng, J Song, B Li, C Zhu… - Journal of Neuroscience …, 2020 - Wiley Online Library
Preterm birth and associated brain injury are the primary cause of cerebral palsy and
developmental disabilities and are among the most serious global health issues that modern …
developmental disabilities and are among the most serious global health issues that modern …