Development and clinical validation of a novel 9-gene prognostic model based on multi-omics in pancreatic adenocarcinoma

D Xu, Y Wang, X Liu, K Zhou, J Wu, J Chen… - Pharmacological …, 2021 - Elsevier
The prognoses of patients with pancreatic adenocarcinoma (PAAD) remain poor due to the
lack of biomarkers for early diagnosis and effective prognosis prediction. RNA sequencing …

Combination of urine exosomal mRNAs and lncRNAs as novel diagnostic biomarkers for bladder cancer

H Huang, J Du, B Jin, L Pang, N Duan, C Huang… - Frontiers in …, 2021 - frontiersin.org
Background The recent discovery of miRNAs and lncRNAs in urine exosomes has emerged
as promising diagnostic biomarkers for bladder cancer (BCa). However, mRNAs as the …

Machine learning applicability for classification of PAD/VCD chemotherapy response using 53 multiple myeloma RNA sequencing profiles

N Borisov, A Sergeeva, M Suntsova, M Raevskiy… - Frontiers in …, 2021 - frontiersin.org
Multiple myeloma (MM) affects~ 500,000 people and results in~ 100,000 deaths annually,
being currently considered treatable but incurable. There are several MM chemotherapy …

Prognostic model based on six PD-1 expression and immune infiltration-associated genes predicts survival in breast cancer

S Junjun, W Yangyanqiu, Z Jing, P Jie, C Jian… - Breast Cancer, 2022 - Springer
Background The prognosis of breast cancer (BC) was associated with the expression of
programmed cell death-1 (PD-1). Methods BC-related expression and clinical data were …

HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis

J Wang, F Xiang, X Liu, X Ma, X Cai… - Oncology …, 2021 - spandidos-publications.com
High‑risk human papillomavirus (HPV) 16 and 18 are the primary cause of cervical cancer
(CC) and long non‑coding RNAs (lncRNAs/lncs) are often abnormally expressed in patients …

A novel endoplasmic stress mediator, Kelch domain containing 7B (KLHDC7B), increased Harakiri (HRK) in the SubAB-induced apoptosis signaling pathway

K Yahiro, K Ogura, H Tsutsuki, S Iyoda, M Ohnishi… - Cell Death …, 2021 - nature.com
Abstract Locus for Enterocyte Effacement (LEE)-positive Shiga-toxigenic Escherichia coli
(STEC) contributes to many global foodborne diseases, with infection characterized by …

Population-scale analysis of common and rare genetic variation associated with hearing loss in adults

K Praveen, L Dobbyn, L Gurski, AH Ayer… - Communications …, 2022 - nature.com
To better understand the genetics of hearing loss, we performed a genome-wide association
meta-analysis with 125,749 cases and 469,497 controls across five cohorts. We identified …

KLHDC7B as a novel diagnostic biomarker in urine exosomal mRNA promotes bladder urothelial carcinoma cell proliferation and migration, inhibits apoptosis

J Hou, H Huang, J Xie, W Yu, H Hao… - Molecular …, 2024 - Wiley Online Library
Bladder cancer is a common kind of urinary system cancer, in which bladder urothelial
carcinoma (BLCA) comprises approximately 90% of all bladder cancer types. In our previous …

[HTML][HTML] Construction and validation of a macrophage polarization-related prognostic index to predict the overall survival in patients with early-stage triple-negative …

H Luo, R Hong, Y Xu, Q Zheng, W Xia, Q Lu… - Gland …, 2023 - ncbi.nlm.nih.gov
Background Triple-negative breast cancer (TNBC) is a highly heterogeneous disease and
the current prognostic system cannot meet the clinical need. Interactions between immune …

The role of pyroptosis-related genes in breast cancer progression

S Wang, D Yang, J Mo, M Chen, R Zhang - Tumor Discovery, 2024 - accscience.com
Breast cancer (BC) is one of the most common malignant cancers affecting females
worldwide. Pyroptosis, a form of programmed cell death associated with inflammation and …