Immune and inflammatory cells in thyroid cancer microenvironment
SM Ferrari, P Fallahi, MR Galdiero, I Ruffilli… - International journal of …, 2019 - mdpi.com
A hallmark of cancer is the ability of tumor cells to avoid immune destruction. Activated
immune cells in tumor microenvironment (TME) secrete proinflammatory cytokines and …
immune cells in tumor microenvironment (TME) secrete proinflammatory cytokines and …
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
SM Wilhelm, L Adnane, P Newell, A Villanueva… - Molecular cancer …, 2008 - AACR
Although patients with advanced refractory solid tumors have poor prognosis, the clinical
development of targeted protein kinase inhibitors offers hope for the future treatment of many …
development of targeted protein kinase inhibitors offers hope for the future treatment of many …
[HTML][HTML] Regulation of CXCR4 signaling
JM Busillo, JL Benovic - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled
receptors, and is directly involved in a number of biological processes including …
receptors, and is directly involved in a number of biological processes including …
Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer
M Ryder, RA Ghossein… - Endocrine-related …, 2008 - erc.bioscientifica.com
Thyroid cancers are infiltrated with tumor-associated macrophages (TAMs), yet their role in
cancer progression is not known. The objectives of this study were to characterize the …
cancer progression is not known. The objectives of this study were to characterize the …
RET tyrosine kinase signaling in development and cancer
E Arighi, MG Borrello, H Sariola - Cytokine & growth factor reviews, 2005 - Elsevier
The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …
CXCR4 and cancer
B Furusato, JS Rhim - Chemokine Receptors in Cancer, 2009 - Springer
The chemokine receptor CXCR4 belongs to the large superfamily of G-protein-coupled
receptors, and is directly involved in a number of biological processes including …
receptors, and is directly involved in a number of biological processes including …
Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
MG Borrello, L Alberti, A Fischer… - Proceedings of the …, 2005 - National Acad Sciences
Rearrangements of the RET receptor tyrosine kinase gene generating RET/PTC oncogenes
are specific to papillary thyroid carcinoma (PTC), the most frequent thyroid tumor. Here, we …
are specific to papillary thyroid carcinoma (PTC), the most frequent thyroid tumor. Here, we …
Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis
The chemokine stroma-derived factor (SDF-1/CXCL12) plays multiple roles in tumor
pathogenesis. It has been demonstrated that CXCL12 promotes tumor growth and …
pathogenesis. It has been demonstrated that CXCL12 promotes tumor growth and …
Thyroid cancer and inflammation
V Guarino, MD Castellone, E Avilla… - Molecular and cellular …, 2010 - Elsevier
Some cancer types are strongly associated with chronic inflammatory or infectious diseases
whereas others are not, but an inflammatory component is present in most human neoplastic …
whereas others are not, but an inflammatory component is present in most human neoplastic …
Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma
S Scala, A Ottaiano, PA Ascierto, M Cavalli… - Clinical Cancer …, 2005 - AACR
Purpose: CXCR4 receptor and its unique ligand, the CXCL12 chemokine, have been
recently implicated in cancer metastasis. Evidence about the role of CXCR4/CXCL12 axis …
recently implicated in cancer metastasis. Evidence about the role of CXCR4/CXCL12 axis …