Alterations in DNAs could not reveal what happened in proteins. The accumulated
alterations of DNAs would change the manifestation of proteins. Therefore, as is the case in …

Proteomics involves the applications of technologies for the identification and quantification
of overall proteins present content of a cell, tissue or an organism. It supplements the other …

Urothelial carcinoma of the bladder comprises two long-recognized disease entities with
distinct molecular features and clinical outcome. Low-grade non-muscle-invasive tumours …

The overexpression of Hdm2 and HdmX is a common mechanism used by many tumor cells
to inactive the p53 tumor suppressor pathway promoting cell survival. Targeting Hdm2 and …

Gastric cancer is a leading cause of mortality due to neoplastic disease. Although early
detection of gastric cancers can decrease the mortality rate, it remains a diagnostic …

Of the diverse analytical tools used in proteomics, protein microarrays possess the greatest
potential for providing fundamental information on protein, ligand, analyte, receptor, and …

Microarrays of proteins and peptides make it possible the screening of thousands of binding
events in a parallel and high throughput fashion; therefore they are emerging as a powerful …

Abstract The phosphatidylinositol 3-kinase (PI3K) pathway is a critical signal transduction
pathway that regulates multiple cellular functions. Aberrant activation of this pathway has …

Protein microarray technology possesses some of the greatest potential for providing direct
information on protein function and potential drug targets. For example, functional protein …

Transthyretin-associated forms of cardiac amyloidosis are fatal protein misfolding diseases
that can be inherited (ATTRm) or acquired (ATTRwt). An accurate diagnosis of ATTR …