Gastrointestinal biofilms in health and disease

JP Motta, JL Wallace, AG Buret, C Deraison… - Nature Reviews …, 2021 - nature.com
Microorganisms colonize various ecological niches in the human habitat, as they do in
nature. Predominant forms of multicellular communities called biofilms colonize human …

Effects of hydrogen sulfide on the microbiome: from toxicity to therapy

AG Buret, T Allain, JP Motta… - Antioxidants & redox …, 2022 - liebertpub.com
Significance: Hydrogen sulfide (H2S), an important regulator of physiology and health, helps
resolve inflammation and promotes tissue repair in the gastrointestinal tract. Recent …

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis

L Deng, F Costa, KJ Blake, S Choi, A Chandrabalan… - Cell, 2023 - cell.com
Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly
exposed to microbes and their products. However, the role of microbes in itch generation is …

[HTML][HTML] Exposure to irregular microplastic shed from baby bottles activates the ROS/NLRP3/Caspase-1 signaling pathway, causing intestinal inflammation

Z Xu, J Shen, L Lin, J Chen, L Wang, X Deng… - Environment …, 2023 - Elsevier
Irregularly shaped microplastics (MPs) released from infant feeding bottles (PP-IFBs) may
exhibit increased cytotoxicity, in contrast to the commonly studied spherical MPs. This study …

Gut microbiota biofilms: from regulatory mechanisms to therapeutic targets

AG Buret, T Allain - Journal of Experimental Medicine, 2023 - rupress.org
Gut microbiota contain communities of viruses, bacteria, fungi, and Eukarya, and live as
biofilms. In health, these biofilms adhere to the intestinal mucus surface without contacting …

[HTML][HTML] Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation

XK Guo, J Wang, VP van Hensbergen, J Liu, H Xu… - Cell Reports, 2023 - cell.com
As highly organized consortia of bacteria, biofilms have long been implicated in aggravating
inflammation. However, our understanding regarding in vivo host-biofilm interactions in the …

Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice

X Mas-Orea, L Rey, L Battut, C Bories… - Communications …, 2023 - nature.com
Opioid-dependent immune-mediated analgesic effects have been broadly reported upon
inflammation. In preclinical mouse models of intestinal inflammatory diseases, the local …

The role of mucin O-glycans in microbiota dysbiosis, intestinal homeostasis, and host-pathogen interactions

E Fekete, AG Buret - American Journal of Physiology …, 2023 - journals.physiology.org
Mucin O-linked glycans are important mediators of host-microbiota-pathogen interactions in
the gastrointestinal tract. The major component of intestinal mucus, the MUC2 mucin, is …

Changes in signalling from faecal neuroactive metabolites following dietary modulation of IBS pain

CJ Tuck, AA Omar, G De Palma, S Osman… - Gut, 2023 - gut.bmj.com
Objective Dietary therapies for irritable bowel syndrome (IBS) have received increasing
interest but predicting which patients will benefit remains a challenge due to a lack of …

[HTML][HTML] Topical application of Lactobacilli successfully eradicates Pseudomonas aeruginosa biofilms and promotes wound healing in chronic wounds

Z Li, S Zhang, F Zuber, S Altenried, A Jaklenec… - Microbes and …, 2023 - Elsevier
Chronic wounds are difficult to treat due to the presence of biofilm which prevents wound
healing. Pseudomonas aeruginosa is one of the most common pathogens found in chronic …