Gastrointestinal biofilms in health and disease
Microorganisms colonize various ecological niches in the human habitat, as they do in
nature. Predominant forms of multicellular communities called biofilms colonize human …
nature. Predominant forms of multicellular communities called biofilms colonize human …
Effects of hydrogen sulfide on the microbiome: from toxicity to therapy
Significance: Hydrogen sulfide (H2S), an important regulator of physiology and health, helps
resolve inflammation and promotes tissue repair in the gastrointestinal tract. Recent …
resolve inflammation and promotes tissue repair in the gastrointestinal tract. Recent …
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis
L Deng, F Costa, KJ Blake, S Choi, A Chandrabalan… - Cell, 2023 - cell.com
Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly
exposed to microbes and their products. However, the role of microbes in itch generation is …
exposed to microbes and their products. However, the role of microbes in itch generation is …
[HTML][HTML] Exposure to irregular microplastic shed from baby bottles activates the ROS/NLRP3/Caspase-1 signaling pathway, causing intestinal inflammation
Z Xu, J Shen, L Lin, J Chen, L Wang, X Deng… - Environment …, 2023 - Elsevier
Irregularly shaped microplastics (MPs) released from infant feeding bottles (PP-IFBs) may
exhibit increased cytotoxicity, in contrast to the commonly studied spherical MPs. This study …
exhibit increased cytotoxicity, in contrast to the commonly studied spherical MPs. This study …
Gut microbiota biofilms: from regulatory mechanisms to therapeutic targets
Gut microbiota contain communities of viruses, bacteria, fungi, and Eukarya, and live as
biofilms. In health, these biofilms adhere to the intestinal mucus surface without contacting …
biofilms. In health, these biofilms adhere to the intestinal mucus surface without contacting …
[HTML][HTML] Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation
As highly organized consortia of bacteria, biofilms have long been implicated in aggravating
inflammation. However, our understanding regarding in vivo host-biofilm interactions in the …
inflammation. However, our understanding regarding in vivo host-biofilm interactions in the …
Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice
X Mas-Orea, L Rey, L Battut, C Bories… - Communications …, 2023 - nature.com
Opioid-dependent immune-mediated analgesic effects have been broadly reported upon
inflammation. In preclinical mouse models of intestinal inflammatory diseases, the local …
inflammation. In preclinical mouse models of intestinal inflammatory diseases, the local …
The role of mucin O-glycans in microbiota dysbiosis, intestinal homeostasis, and host-pathogen interactions
E Fekete, AG Buret - American Journal of Physiology …, 2023 - journals.physiology.org
Mucin O-linked glycans are important mediators of host-microbiota-pathogen interactions in
the gastrointestinal tract. The major component of intestinal mucus, the MUC2 mucin, is …
the gastrointestinal tract. The major component of intestinal mucus, the MUC2 mucin, is …
Changes in signalling from faecal neuroactive metabolites following dietary modulation of IBS pain
CJ Tuck, AA Omar, G De Palma, S Osman… - Gut, 2023 - gut.bmj.com
Objective Dietary therapies for irritable bowel syndrome (IBS) have received increasing
interest but predicting which patients will benefit remains a challenge due to a lack of …
interest but predicting which patients will benefit remains a challenge due to a lack of …
[HTML][HTML] Topical application of Lactobacilli successfully eradicates Pseudomonas aeruginosa biofilms and promotes wound healing in chronic wounds
Chronic wounds are difficult to treat due to the presence of biofilm which prevents wound
healing. Pseudomonas aeruginosa is one of the most common pathogens found in chronic …
healing. Pseudomonas aeruginosa is one of the most common pathogens found in chronic …