Obesity continues to be among the top health concerns across the globe. Despite our failure
to contain the high prevalence of obesity, we now have a better understanding of its …

Clinical and pathophysiological studies have shown type 2 diabetes to be a condition mainly
caused by excess, yet reversible, fat accumulation in the liver and pancreas. Within the liver …

Energy restriction induces physiological effects that hinder further weight loss. Thus,
deliberate periods of energy balance during weight loss interventions may attenuate these …

Results: For the N= 19 CON and N= 17 INT who completed the intervention per protocol,
weight loss was greater for INT (14.1±5.6 vs 9.1±2.9 kg; P< 0.001). INT had greater FM loss …

Weight loss resulting from an exercise intervention tends to be lower than predicted. Modest
weight loss can arise from an increase in energy intake, physiological reductions in resting …

Background It has been proposed that habitual physical activity improves appetite control;
however, the evidence has never been systematically reviewed. Objective To examine …

Importance There is no definitive evidence that changes in physical activity/sedentary
behavior can be maintained long term in individuals with type 2 diabetes. Objective To …

In many interventions that are based on an exercise program intended to induce weight loss,
the mean weight loss observed is modest and sometimes far less than the individual …

The current obesogenic environment promotes physical inactivity and food consumption in
excess of energy requirements, two important modifiable risk factors influencing energy …

The twin cycle hypothesis postulated that type 2 diabetes was a result of excess liver fat
causing excess supply of fat to the pancreas with resulting dysfunction of both organs. If this …