Two chaperones locked in an embrace: structure and function of the ribosome-associated complex RAC

Y Zhang, I Sinning, S Rospert - Nature Structural & Molecular Biology, 2017 - nature.com
Chaperones, which assist protein folding are essential components of every living cell. The
yeast ribosome-associated complex (RAC) is a chaperone that is highly conserved in …

Regulation of p53 and cancer signaling by heat shock protein 40/J-domain protein family members

A Kaida, T Iwakuma - International journal of molecular sciences, 2021 - mdpi.com
Heat shock proteins (HSPs) are molecular chaperones that assist diverse cellular activities
including protein folding, intracellular transportation, assembly or disassembly of protein …

Histone mono-ubiquitination in transcriptional regulation and its mark on life: emerging roles in tissue development and disease

L Oss-Ronen, T Sarusi, I Cohen - Cells, 2022 - mdpi.com
Epigenetic regulation plays an essential role in driving precise transcriptional programs
during development and homeostasis. Among epigenetic mechanisms, histone mono …

Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation

T Papadopoulou, A Kaymak, S Sayols, H Richly - Cell Cycle, 2016 - Taylor & Francis
Mediator is considered an enhancer of RNA-Polymerase II dependent transcription but its
function and regulation in pluripotent mouse embryonic stem cells (mESCs) remains …

ZRF1: a novel epigenetic regulator of stem cell identity and cancer

L Aloia, S Demajo, L Di Croce - Cell Cycle, 2015 - Taylor & Francis
The Zuotin-related factor 1, ZRF1, has recently been identified as an epigenetic regulator of
gene transcription in stem cells and cancer. During differentiation of human teratocarcinoma …

ZRF1 controls oncogene-induced senescence through the INK4-ARF locus

JD Ribeiro, L Morey, A Mas, A Gutierrez, NM Luis… - Oncogene, 2013 - nature.com
The reactivation of the INK4-ARF locus, which is epigenetically repressed by Polycomb
proteins in healthy cells, is a hallmark of senescence. One mechanism of reactivating …

HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation

B Hu, S Li, X Zhang, X Zheng - Nucleic acids research, 2014 - academic.oup.com
Histone H2A ubiquitination plays critical roles in transcriptional repression and
deoxyribonucleic acid (DNA) damage response. More attention has been focused on …

Functional conservation and divergence of J-domain-containing ZUO1/ZRF orthologs throughout evolution

DH Chen, Y Huang, C Liu, Y Ruan, WH Shen - Planta, 2014 - Springer
Main conclusion Review and phylogenic analysis on ZUO1/ZRF orthologs. Abstract Heat
shock protein 40s (Hsp40s), also known as J-proteins, are conserved in prokaryotes and …

Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma

T Imamura, S Komatsu, D Ichikawa, M Miyamae… - …, 2018 - academic.oup.com
Abstract Zuotin-related factor 1 (ZRF1) is a recently characterized epigenetic factor involved
in transcriptional regulation and is highly overexpressed in several malignancies, but it is not …

Identification and characteristics of the testes-specific gene, Ccdc38, in mice

SR Lin, YC Li, ML Luo, H Guo… - Molecular …, 2016 - spandidos-publications.com
Distinguishing the testes-specific genes in different species may disclose key genes
associated with testes-specific functions and provide sufficient information for the study and …