[HTML][HTML] Unraveling plant natural chemical diversity for drug discovery purposes
E Lautie, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …
benefit from the immense natural chemical diversity is a concern in many laboratories …
[HTML][HTML] Application of genetics and biotechnology for improving medicinal plants
M Niazian - Planta, 2019 - Springer
Main conclusion Plant tissue culture has been used for conservation, micropropagation, and
in planta overproduction of some pharma molecules of medicinal plants. New biotechnology …
in planta overproduction of some pharma molecules of medicinal plants. New biotechnology …
[HTML][HTML] Advances in synthetic biology and biosafety governance
J Li, H Zhao, L Zheng, W An - Frontiers in bioengineering and …, 2021 - frontiersin.org
Tremendous advances in the field of synthetic biology have been witnessed in multiple
areas including life sciences, industrial development, and environmental bio-remediation …
areas including life sciences, industrial development, and environmental bio-remediation …
CRISPR/Cas genome editing to optimize pharmacologically active plant natural products
A Dey - Pharmacological Research, 2021 - Elsevier
Since time immemorial, human use medicinal plants as sources of food, therapy and
industrial purpose. Classical biotechnology and recent next-generation sequencing (NGS) …
industrial purpose. Classical biotechnology and recent next-generation sequencing (NGS) …
[HTML][HTML] Light-activated green drugs: How we can use them in photodynamic therapy and mass-produce them with biotechnological tools
Photodynamic therapy (PDT) is a promising therapeutic approach to manage the resolution
of cancer. Plants in nature are one of the potential sources for obtaining new …
of cancer. Plants in nature are one of the potential sources for obtaining new …
[HTML][HTML] Insights into applications and strategies for discovery of microbial bioactive metabolites
Secondary metabolites of microbial origin are structurally diverse and functionally versatile
compounds that offer selective advantages to the producing organism. Production of these …
compounds that offer selective advantages to the producing organism. Production of these …
Characterization and engineering of a Clostridium glycine riboswitch and its use to control a novel metabolic pathway for 5-aminolevulinic acid production in …
L Zhou, J Ren, Z Li, J Nie, C Wang… - ACS synthetic biology, 2019 - ACS Publications
A riboswitch, a regulatory RNA that controls gene expression by specifically binding a
ligand, is an attractive genetic element for the control of conditional gene expression and …
ligand, is an attractive genetic element for the control of conditional gene expression and …
[HTML][HTML] A severe leakage of intermediates to shunt products in acarbose biosynthesis
Q Zhao, Y Luo, X Zhang, Q Kang, D Zhang… - Nature …, 2020 - nature.com
The α-glucosidase inhibitor acarbose, produced by Actinoplanes sp. SE50/110, is a well-
known drug for the treatment of type 2 diabetes mellitus. However, the largely unexplored …
known drug for the treatment of type 2 diabetes mellitus. However, the largely unexplored …
CRISPR-Cas system in microbial hosts for terpenoid production
LL Chu - Critical Reviews in Biotechnology, 2022 - Taylor & Francis
Terpenoids represent the largest group of secondary metabolites with variable structures
and functions. Terpenoids are well known for their beneficial application in human life, such …
and functions. Terpenoids are well known for their beneficial application in human life, such …