[HTML][HTML] Unraveling plant natural chemical diversity for drug discovery purposes

E Lautie, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …

[HTML][HTML] Application of genetics and biotechnology for improving medicinal plants

M Niazian - Planta, 2019 - Springer
Main conclusion Plant tissue culture has been used for conservation, micropropagation, and
in planta overproduction of some pharma molecules of medicinal plants. New biotechnology …

[HTML][HTML] Advances in synthetic biology and biosafety governance

J Li, H Zhao, L Zheng, W An - Frontiers in bioengineering and …, 2021 - frontiersin.org
Tremendous advances in the field of synthetic biology have been witnessed in multiple
areas including life sciences, industrial development, and environmental bio-remediation …

CRISPR/Cas genome editing to optimize pharmacologically active plant natural products

A Dey - Pharmacological Research, 2021 - Elsevier
Since time immemorial, human use medicinal plants as sources of food, therapy and
industrial purpose. Classical biotechnology and recent next-generation sequencing (NGS) …

[HTML][HTML] Light-activated green drugs: How we can use them in photodynamic therapy and mass-produce them with biotechnological tools

E Foresto, P Gilardi, LE Ibarra, IS Cogno - Phytomedicine Plus, 2021 - Elsevier
Photodynamic therapy (PDT) is a promising therapeutic approach to manage the resolution
of cancer. Plants in nature are one of the potential sources for obtaining new …

[HTML][HTML] Insights into applications and strategies for discovery of microbial bioactive metabolites

D Maithani, A Sharma, S Gangola, P Chaudhary… - Microbiological …, 2022 - Elsevier
Secondary metabolites of microbial origin are structurally diverse and functionally versatile
compounds that offer selective advantages to the producing organism. Production of these …

Characterization and engineering of a Clostridium glycine riboswitch and its use to control a novel metabolic pathway for 5-aminolevulinic acid production in …

L Zhou, J Ren, Z Li, J Nie, C Wang… - ACS synthetic biology, 2019 - ACS Publications
A riboswitch, a regulatory RNA that controls gene expression by specifically binding a
ligand, is an attractive genetic element for the control of conditional gene expression and …

Synthetic biology of yeast

Z Liu, Y Zhang, J Nielsen - Biochemistry, 2019 - ACS Publications
With the rapid development of DNA synthesis and next-generation sequencing, synthetic
biology that aims to standardize, modularize, and innovate cellular functions, has achieved …

[HTML][HTML] A severe leakage of intermediates to shunt products in acarbose biosynthesis

Q Zhao, Y Luo, X Zhang, Q Kang, D Zhang… - Nature …, 2020 - nature.com
The α-glucosidase inhibitor acarbose, produced by Actinoplanes sp. SE50/110, is a well-
known drug for the treatment of type 2 diabetes mellitus. However, the largely unexplored …

CRISPR-Cas system in microbial hosts for terpenoid production

LL Chu - Critical Reviews in Biotechnology, 2022 - Taylor & Francis
Terpenoids represent the largest group of secondary metabolites with variable structures
and functions. Terpenoids are well known for their beneficial application in human life, such …