Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Type 1 diabetes is considered to be an autoimmune disease in which T lymphocytes
infiltrate the islets of pancreas and destroy the insulin producing beta cell population …

The lymphocytes from 59 newly diagnosed type 1 diabetic patients and 38 normal control
subjects were examined for the presence of human cytomegalovirus (CMV) genome by …

Of 37 pancreases removed at necropsy from patients with type 1 diabetes 34 had residual β
cells. In 33 of the 34 the β cells were positive for immunoreactive α-interferon, and this …

Insulin-dependent diabetes mellitus (IDDM) is thought to result from the autoimmune
destruction of the insulin-producing beta cells of the pancreas. Years before IDDM …

Aims/hypothesis It is thought that enterovirus infections cause beta-cell damage and
contribute to the development of Type 1 diabetes by replicating in the pancreatic islets. We …

Type 1 diabetes results from the destruction of pancreatic beta cells. Genetic factors are
believed to be a major component for the development of type 1diabetes, but the …

The primary objective of this multicenter, multinational, epidemiological study is the
identification of infectious agents, dietary factors, or other environmental exposures that are …

During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly,
reaching percentages of 3% annually worldwide. This increase suggests that besides …

Highlights•Enteroviral infection has been long-associated with type 1 diabetes in
epidemiological studies.•β-Cells express a specific enteroviral receptor isoform, CAR-SIV …