The paraoxonase (PON) gene family includes three proteins, PON1, PON2 and PON3.
PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert …

Multiple myeloma is a form of plasma cell neoplasm that accounts for approximately 10% of
all hematological malignancies. Recently, several novel drugs have been discovered that …

Extensive research has been carried out to understand and elucidate the mechanisms of
paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular …

Raised oxidative stress and abnormal redox status are typical features of multiple myeloma
cells, and the identification of the intimate mechanisms that regulate the relationships …

Background Esterase enzymes differ in substrate specificity and biological function and may
display dysregulated expression in cancer. This study evaluated the biological significance …

Esterase enzymes are a family of hydrolases that catalyze the breakdown and formation of
ester bonds. Esterases have gained a prominent position in today's world's industrial …

Background Multiple myeloma (MM) is an incurable plasma cell malignancy. Red cell
distribution width (RDW) is a prognostic marker in various diseases, solid tumors, and …

Objectives: The etiology of multiple myeloma (MM) is not exactly known. This study
investigated the role of thiol/disulfide homeostasis in the etiopathogenesis of MM. Methods …

Abstract High Density Lipoprotein (HDL) has been witnessed to possess a range of different
functions that contribute to its atheroprotective effects. These functions are: the promotion of …

Inflammation and oxidative stress play a significant role in the pathogenesis of acute
myeloid leukemia. While myeloperoxidase carries pro-oxidant effects, HDL-cholesterol and …