IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Alterations of cell death pathways, including apoptosis and the neutrophil specific kind of
death called NETosis, can represent a potential source of autoantigens. Defects in the …

The role of various environmental factors in the pathogenesis of immune mediated diseases
is well established. Of which, factors entailing an immune adjuvant activity such as infectious …

Interleukin 6 (IL-6), which was originally identified as a B-cell differentiation factor, is now
known to be a multifunctional cytokine that regulates the immune response, hematopoiesis …

Ten years have passed since the molecular cloning of interleukin 6 (IL-6) in 1986. IL-6 is a
typical cytokine, exhibiting functional pleiotropy and redundancy. IL-6 is involved in the …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …

Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs
and used to treat and/or manage human ailments such as metabolic, cardiovascular …

In 2011 a new syndrome termed 'ASIA Autoimmune/Inflammatory Syndrome Induced by
Adjuvants' was defined pointing to summarize for the first time the spectrum of immune …

Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a
murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody …

Macrophages rapidly engulf apoptotic cells to limit the release of noxious cellular contents
and to restrict autoimmune responses against self antigens. Although factors participating in …