Block-and-lock strategies to cure HIV infection
G Vansant, A Bruggemans, J Janssens, Z Debyser - Viruses, 2020 - mdpi.com
Today HIV infection cannot be cured due to the presence of a reservoir of latently infected
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …
Block and lock HIV cure strategies to control the latent reservoir
CL Ahlenstiel, G Symonds, SJ Kent… - Frontiers in cellular and …, 2020 - frontiersin.org
The HIV latent reservoir represents the major challenge to cure development. Residing in
resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary …
resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary …
The chromatin landscape at the HIV-1 provirus integration site determines viral expression
HIV-1 persists lifelong in memory cells of the immune system as latent provirus that
rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an …
rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an …
Capsid-labelled HIV to investigate the role of capsid during nuclear import and integration
I Zurnic Bönisch, L Dirix, V Lemmens… - Journal of …, 2020 - Am Soc Microbiol
The HIV-1 capsid protein performs multiple roles in virus replication both during assembly
and particle release and during virus trafficking into the nucleus. In order to decipher the …
and particle release and during virus trafficking into the nucleus. In order to decipher the …
Single-cell imaging shows that the transcriptional state of the HIV-1 provirus and its reactivation potential depend on the integration site
Current antiretroviral treatment fails to cure HIV-1 infection since latent provirus resides in
long-lived cellular reservoirs, rebounding whenever therapy is discontinued. The molecular …
long-lived cellular reservoirs, rebounding whenever therapy is discontinued. The molecular …
GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture
A Bruggemans, G Vansant… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
The ability of HIV to integrate into the host genome and establish latent reservoirs is the
main hurdle preventing an HIV cure. LEDGINs are small-molecule integrase inhibitors that …
main hurdle preventing an HIV cure. LEDGINs are small-molecule integrase inhibitors that …
Epigenetic crosstalk in chronic infection with HIV-1
UC Lange, R Verdikt, A Ait-Ammar… - Seminars in …, 2020 - Springer
Abstract Human immunodeficiency virus 1 (HIV-1) replicates through the integration of its
viral DNA into the genome of human immune target cells. Chronically infected individuals …
viral DNA into the genome of human immune target cells. Chronically infected individuals …
Interests of the non-human primate models for HIV cure research
G Terrade, N Huot, C Petitdemange, M Lazzerini… - Vaccines, 2021 - mdpi.com
Non-human primate (NHP) models are important for vaccine development and also
contribute to HIV cure research. Although none of the animal models are perfect, NHPs …
contribute to HIV cure research. Although none of the animal models are perfect, NHPs …
HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification and flanking linker …
ABSTRACT HIV-1 DNA is preferentially integrated into chromosomal hot spots by the
preintegration complex (PIC). To understand the mechanism, we measured the DNA …
preintegration complex (PIC). To understand the mechanism, we measured the DNA …
Integrase inhibitors: current protagonists in antiretroviral therapy
Since HIV was identified as the etiological agent of AIDS, there have been significant
advances in antiretroviral therapy (ART) that has reduced morbidity/mortality. Still, the viral …
advances in antiretroviral therapy (ART) that has reduced morbidity/mortality. Still, the viral …