Cerebral small vessel disease (SVD) causes lacunar stroke and intracerebral hemorrhage,
and is the most common pathology underlying vascular cognitive impairment. Increasingly …

Background Alzheimer's disease (AD) is highly intertwined with sleep disturbances
throughout its whole natural history. Sleep consists of a major compound of the functionality …

Abstract The Rotterdam Study is a population-based cohort study, started in 1990 in the
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …

Arteriolosclerosis is common in older brains and related to cognitive and motor impairment.
We compared the severity of arteriolosclerosis and its associations with cerebrovascular …

Background Perivascular spaces (PVS) are fluid-filled compartments that dilate in response
to many different conditions. A high burden of enlarged PVS (EPVS) in the centrum …

Background and Objectives Previous studies have linked the MRI measures of perivascular
spaces (PVSs), diffusivity along the perivascular spaces (DTI-ALPS), and free water (FW) to …

Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer's disease
(AD) pathologies co-existing with cerebral small vessel disease (CSVD) is the most common …

Vascular dementia (VaD) is a prevalent form of cognitive impairment with underlying
vascular etiology. In this review, we examine recent genetic advancements in our …

Introduction Congenital and developmental intracranial cysts represent a large
heterogenous group with varied presentations and etiologies. They can range from normal …

BACKGROUND: Previous studies yielded conflicting results about the influence of blood
pressure (BP) and antihypertensive treatment on cerebral small vessel disease. Here, we …