Viruses survive often harsh host environments, yet we know little about the strategies they
utilize to adapt and subsist given their limited genomic resources. We are beginning to …

Inactivated and live attenuated vaccines have improved human life and significantly reduced
morbidity and mortality of several human infectious diseases. However, these vaccines have …

RNA viruses are unique in their evolutionary capacity, exhibiting high mutation rates and
frequent recombination. They rapidly adapt to environmental changes, such as shifts in …

Arthropod-borne viruses pose a major threat to global public health. Thus, innovative
strategies for their control and prevention are urgently needed. Here, we exploit the natural …

Defective interfering particles (DIPs), derived naturally from viral particles, are not able to
replicate on their own. Several studies indicate that DIPs exert antiviral effects via multiple …

Negative-sense RNA virus populations are composed of diverse viral components that
interact to form a community and shape the outcome of virus infections. At the genomic level …

Defective interfering particles (DIPs) are particles containing defective viral genomes (DVGs)
generated during viral replication. DIPs have been found in various RNA viruses, especially …

Defective interfering particles (DIPs) are virus mutants that lack essential genes for growth.
In coinfections with helper virus, the diversion of viral proteins to the replication and …

Viral particles are used in medical applications as vaccines or gene therapy vectors. In order
to obtain product of high purity, potency and safety for medical use purification of virus …

Defective viral genomes (DVGs) generated during RNA virus replication determine infection
outcome by triggering innate immunity, diminishing virulence, and, in many cases …