Simple Summary Colorectal cancer (CRC) is the third-most diagnosed cancer and the
second-leading cause of cancer-related deaths worldwide. Limitations in early and accurate …

Aberrant RNA modifications lead to dysregulated gene expression and cancer progression.
Ribosomal RNA (rRNA) accounts for more than 80% of a cell's total RNA, but the functions …

Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …

Abstract Isocitrate dehydrogenase 1 and 2 (IDH) are mutated in multiple cancers and drive
production of (R)-2-hydroxyglutarate (2HG). We identified a lipid synthesis enzyme [acetyl …

Hydrolyzed guar gum has gained attention as an anti-obesity agent; however, few studies
have focused on its role in amelioration of hepatic-associated metabolic processes. Here …

Identifying how small molecules act to kill malaria parasites can lead to new “chemically
validated” targets. By pressuring Plasmodium falciparum asexual blood stage parasites with …

Prostate cancer (PCa) is a carcinoma in which fatty acids are abundant. Fatty acid
metabolism is rewired during PCa development. Although PCa can be treated with hormone …

Metabolic Reprogramming is a sign of tumor, and as one of the three major substances
metabolism, lipid has an obvious impact. Abnormal lipid metabolism is related to the …

Health risks caused by crucial environmental carcinogens N-nitrosamines triggered
ubiquitous attention. As the liver exerted vital function through metabolic process, lipid …

Background Alcohol consumption has been shown to disrupt hepatic lipid homeostasis.
Long-chain acyl-CoA synthetase 1 (ACSL1) critically regulates hepatic fatty acid metabolism …