The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co‐stimulatory …
D Hollenbaugh, LS Grosmaire, CD Kullas… - The EMBO …, 1992 - embopress.org
Signals delivered to B cells via CD40 can synergize with those provided by other B cell
surface receptors to induce B cell proliferation and antibody class switching as well as …
surface receptors to induce B cell proliferation and antibody class switching as well as …
Disorders of renal tubular phosphate transport
HS Tenenhouse, H Murer - Journal of the American Society of …, 2003 - journals.lww.com
The kidney plays a major role in the maintenance of inorganic phosphate (P i) homeostasis
and, as such, ensures that an adequate supply of this ubiquitous anion is available for …
and, as such, ensures that an adequate supply of this ubiquitous anion is available for …
FGF23 is processed by proprotein convertases but not by PHEX
A Benet-Pagès, B Lorenz-Depiereux, H Zischka… - Bone, 2004 - Elsevier
X-linked hypophosphatemia (XLH) and autosomal dominant hypophosphatemic rickets
(ADHR) are characterized by renal phosphate wasting, rickets, and osteomalacia. ADHR is …
(ADHR) are characterized by renal phosphate wasting, rickets, and osteomalacia. ADHR is …
Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit
Neurons produce and release neuropeptides to communicate with one another. Despite
their importance in brain function, circuit-based mechanisms of peptidergic transmission are …
their importance in brain function, circuit-based mechanisms of peptidergic transmission are …
Neutral endopeptidase can hydrolyze β-amyloid (1–40) but shows no effect on β-amyloid precursor protein metabolism
S Howell, J Nalbantoglu, P Crine - Peptides, 1995 - Elsevier
High performance liquid chromatographic analyses of incubations of β-amyloid (1–40) with
neutral endopeptidase revealed at least nine product peaks, indicating that neutral …
neutral endopeptidase revealed at least nine product peaks, indicating that neutral …
Novel phosphate-regulating genes in the pathogenesis of renal phosphate wasting disorders
HS Tenenhouse, Y Sabbagh - Pflügers Archiv, 2002 - Springer
Over the past decade, three classes of Na/Pi cotransporters have been identified in
mammalian kidney. The type IIa Na/Pi cotransporter, Npt2, is the most abundant and is …
mammalian kidney. The type IIa Na/Pi cotransporter, Npt2, is the most abundant and is …
Developmental Expression and Tissue Distribution of Phex Protein: Effect of the Hyp Mutation and Relationship to Bone Markers
AF Ruchon, HS Tenenhouse… - Journal of Bone and …, 2000 - academic.oup.com
Mutations in PHEX, a phosphate‐regulating gene with homology to endopeptidases on the
X chromosome, are responsible for X‐linked hypophosphatemia (XLH). The murine Hyp …
X chromosome, are responsible for X‐linked hypophosphatemia (XLH). The murine Hyp …
Proteolytic Processing of Big Endothelin-3 by the Kell Blood Group Protein: Presented in part in abstract form at the 40th annual meeting of the American Society of …
S Lee, M Lin, A Mele, Y Cao, J Farmar… - Blood, The Journal …, 1999 - ashpublications.org
Kell blood group protein shares a consensus sequence (HEXXH) with a large family of zinc-
dependent endopeptidases. Kell has closest homology with neutral endopeptidase 24.11 …
dependent endopeptidases. Kell has closest homology with neutral endopeptidase 24.11 …
Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107–139 as a substrate and osteocalcin, PPi and …
G BOILEAU, HS TENENHOUSE… - Biochemical …, 2001 - portlandpress.com
Mutations in the PHEX gene (̲phosphate-regulating gene with homologies to
̲endopeptidases on the ̲X chromosome) are responsible for X-linked …
̲endopeptidases on the ̲X chromosome) are responsible for X-linked …
Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family
G GHADDAR, AF RUCHON… - Biochemical …, 2000 - portlandpress.com
Because of their roles in controlling the activity of several bio-active peptides, members of
the neprilysin family of zinc metallopeptidases have been identified as putative targets for …
the neprilysin family of zinc metallopeptidases have been identified as putative targets for …