The purpose of this study was to determine the toxicological and pharmacokinetic properties
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …

One-carbon metabolism is a central metabolic pathway critical for the biosynthesis of several
amino acids, methyl group donors, and nucleotides. The pathway mostly relies on the …

Cancer cells modulate their metabolic activities to adapt to their growth and proliferation.
Despite advances in breast cancer biology having led to the widespread use of molecular …

Oral squamous cell carcinoma (OSCC) is a frequent threatening head and neck malignancy.
Serine hydroxymethyltransferase 2 (SHMT2) was identified to be upregulated in OSCC and …

Glycyrrhetinic acid (GA) is a natural product of licorice with mitochondria targeting properties
and shows broad anticancer activities, but its targets and underlying mechanisms remain …

Abstract Background One‐carbon (1C) metabolism is a metabolic network that plays
essential roles in biological reactions. In 1C metabolism, a series of nutrients are used to …

The one-carbon metabolism (OCM) pathway provides purines and thymidine for synthesis of
nucleic acids required for cell division, and S-adenosyl methionine for polyamine and …

Anaplastic thyroid cancer (ATC) is one of the most aggressive and lethal tumor types,
characterized by loss of differentiation, epithelial-to-mesenchymal transition, extremely high …

Temozolomide (TMZ) is a commonly used chemotherapeutic agent for glioblastoma (GBM),
but acquired drug resistance prevents its therapeutic efficacy. We investigated potential …

Abstract β-hydroxy amino acids, such as serine, threonine, and phenylserine, are important
compounds for medical purposes. To date, there has been only limited exploration of …