PI3K signaling-regulated metabolic reprogramming: from mechanism to application

WY Su, LY Tian, LP Guo, LQ Huang, WY Gao - Biochimica et Biophysica …, 2023 - Elsevier
Oncogenic signaling involved in tumor metabolic reprogramming. Tumorigenesis was not
only determined by the mutations or deletion of oncogenes but also accompanied by the …

[HTML][HTML] Celf family proteins in cancer: Highlights on the rna-binding protein/noncoding rna regulatory axis

M Nasiri-Aghdam, TC Garcia-Garduño… - International journal of …, 2021 - mdpi.com
Post-transcriptional modifications to coding and non-coding RNAs are unquestionably a
pivotal way in which human mRNA and protein diversity can influence the different phases …

[HTML][HTML] The RNA-binding protein CELF2 inhibits ovarian cancer progression by stabilizing FAM198B

Q Guo, Y Wu, X Guo, L Cao, F Xu, H Zhao, J Zhu… - … Therapy-Nucleic Acids, 2021 - cell.com
An increasing number of studies have clarified the functional roles of RNA-binding proteins
(RBPs) in driving post-transcriptional mechanisms of cancer progression. In this study, we …

[HTML][HTML] CD44v3 is a marker of invasive cancer stem cells driving metastasis in gastric carcinoma

J Giraud, L Seeneevassen, B Rousseau, D Bouriez… - Gastric Cancer, 2023 - Springer
Abstract Background Cancer stem cells (CSCs) are at the origin of tumour initiation and
progression in gastric adenocarcinoma (GC). However, markers of metastasis-initiating cells …

Methylated DNA markers for plasma detection of ovarian cancer: discovery, validation, and clinical feasibility

LM Marinelli, JB Kisiel, SW Slettedahl… - Gynecologic …, 2022 - Elsevier
Objective Aberrant DNA methylation is an early event in carcinogenesis which could be
leveraged to detect ovarian cancer (OC) in plasma. Methods DNA from frozen OC tissues …

Hypoxic colorectal cancer-secreted exosomes deliver miR-210-3p to normoxic tumor cells to elicit a protumoral effect

L Ge, F Zhou, J Nie, X Wang… - Experimental Biology and …, 2021 - journals.sagepub.com
Hypoxia, the most common feature in the tumor microenvironment, is closely related to tumor
malignant progression and poor patient's prognosis. Exosomes, initially recognized as …

[HTML][HTML] CELF2 Sustains a Proliferating/OLIG2+ Glioblastoma Cell Phenotype via the Epigenetic Repression of SOX3

L Turchi, N Sakakini, G Saviane, B Polo… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastomas, primitive infiltrating brain tumors, are a real public health
problem because of their dismal prognosis. The persistence of aggressive tumor stem cells …

Genetic and Clinicopathologic Characteristics of Papillary Thyroid Carcinoma in the Chinese Population: High BRAF Mutation Allele Frequency, Multiple Driver Gene Mutations …

Z Wang, P Tang, S Hua, J Gao, B Zhang… - OncoTargets and …, 2022 - Taylor & Francis
Purpose To describe the genetic landscape and clinical characteristics of Chinese patients
diagnosed with papillary thyroid cancer (PTC) and to determine which high-risk genetic …

miR‐363‐3p induces EMT via the Wnt/β‐catenin pathway in glioma cells by targeting CELF2

B Fan, B Su, G Song, X Liu, Z Yan… - Journal of Cellular …, 2021 - Wiley Online Library
In our previous study, we reported that CELF2 has a tumour‐suppressive function in glioma.
Here, we performed additional experiments to elucidate better its role in cancer. The …

CELF2 is a candidate prognostic and immunotherapy biomarker in triple‐negative breast cancer and lung squamous cell carcinoma: A pan‐cancer analysis

L Wang, Z Liu, L Liu, C Guo, D Jiao, L Li… - Journal of cellular …, 2021 - Wiley Online Library
CUGBP Elav‐like family member 2 (CELF2) plays crucial roles in the development and
activation of T cell. However, the impacts of CELF2 on tumour‐infiltrating immune cells …