Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans

T Zheng, M Jing, T Gong, J Yan, X Wang… - Journal of Oral …, 2023 - Taylor & Francis
Background Dental caries is a chronic, multifactorial and biofilm-mediated oral bacterial
infection affecting almost every age group and every geographical region. Streptococcus …

Antibacterial activities of anthraquinones: structure–activity relationships and action mechanisms

T Qun, T Zhou, J Hao, C Wang, K Zhang, J Xu… - RSC Medicinal …, 2023 - pubs.rsc.org
With the increasing prevalence of untreatable infections caused by antibiotic-resistant
bacteria, the discovery of new drugs from natural products has become a hot research topic …

Antimicrobial Activity of Cinnamaldehyde on Streptococcus mutans Biofilms

Z He, Z Huang, W Jiang, W Zhou - Frontiers in microbiology, 2019 - frontiersin.org
Streptococcus mutans is considered the most relevant bacteria in the transition of non-
pathogenic commensal oral microbiota to biofilms which contribute to the dental caries …

[HTML][HTML] Rhein: A novel antibacterial compound against Streptococcus mutans infection

V Folliero, F Dell'Annunziata, E Roscetto… - Microbiological …, 2022 - Elsevier
Streptococcus mutans (S. mutans) is considered the main causative agent of dental caries.
The study aims to evaluate the antimicrobial activity of a natural plant product, pure 4, 5'' …

Cytotoxicity and antimicrobial action of selected phytochemicals against planktonic and sessile Streptococcus mutans

M Ribeiro, J Malheiro, L Grenho, MH Fernandes… - PeerJ, 2018 - peerj.com
Background Dental caries remains the most prevalent and costly oral infectious disease
worldwide, encouraging the search for new and more effective antimicrobials. Therefore, the …

Repeated Exposure of Vancomycin to Vancomycin-Susceptible Staphylococcus aureus (VSSA) Parent Emerged VISA and VRSA Strains with Enhanced Virulence …

A Nguyen, J Roy, JH Kim, KH Yun, W Lee, KK Kim… - Journal of …, 2024 - Springer
The emergence of resistance against the last-resort antibiotic vancomycin in staphylococcal
infections is a serious concern for human health. Although various drug-resistant pathogens …

Design and evaluation of substrate–product analog inhibitors for racemases and epimerases utilizing a 1, 1-proton transfer mechanism

SL Bearne - Methods in Enzymology, 2023 - Elsevier
Racemases and epimerases catalyze the inversion of stereochemistry at asymmetric carbon
atoms to generate stereoisomers that often play important roles in normal and pathological …

[HTML][HTML] Contribution of the murI gene encoding glutamate racemase in the motility and virulence of Ralstonia solanacearum

K Choi, GJ Son, S Ahmad, SY Lee… - The Plant Pathology …, 2020 - ncbi.nlm.nih.gov
Bacterial traits for virulence of Ralstonia solanacearum causing lethal wilt in plants were
extensively studied but are not yet fully understood. Other than the known virulence factors …

Significance of Glutamate Racemase for the Viability and Cell Wall Integrity of Streptococcus iniae

M Muhammad, J Bai, AJ Alhassan, H Sule, J Ju… - Biochemistry …, 2020 - Springer
Streptococcus iniae is a pathogenic and zoonotic bacterium responsible for human diseases
and mortality of many fish species. Recently, this bacterium has demonstrated an increasing …

Changes in quaternary structure cause a kinetic asymmetry of glutamate racemase‐catalyzed homocysteic acid racemization

J Mackie, H Kumar, SL Bearne - FEBS letters, 2018 - Wiley Online Library
Glutamate racemases (GR) catalyze the racemization of d‐and l‐glutamate and are targets
for the development of antibiotics. We demonstrate that GR from the periodontal pathogen …