T cell-mediated immunity to malaria
Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
Malaria: progress, perils, and prospects for eradication
There are still approximately 500 million cases of malaria and 1 million deaths from malaria
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …
Sterile protection against human malaria by chemoattenuated PfSPZ vaccine
B Mordmüller, G Surat, H Lagler, S Chakravarty… - Nature, 2017 - nature.com
A highly protective malaria vaccine would greatly facilitate the prevention and elimination of
malaria and containment of drug-resistant parasites. A high level (more than 90%) of …
malaria and containment of drug-resistant parasites. A high level (more than 90%) of …
Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine
RA Seder, LJ Chang, ME Enama, KL Zephir… - Science, 2013 - science.org
Consistent, high-level, vaccine-induced protection against human malaria has only been
achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites …
achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites …
Protection against malaria at 1 year and immune correlates following PfSPZ vaccination
AS Ishizuka, KE Lyke, A DeZure, AA Berry, TL Richie… - Nature medicine, 2016 - nature.com
Abstract An attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) vaccine, PfSPZ
Vaccine, is highly protective against controlled human malaria infection (CHMI) 3 weeks …
Vaccine, is highly protective against controlled human malaria infection (CHMI) 3 weeks …
Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity
JE Epstein, K Tewari, KE Lyke, BKL Sim, PF Billingsley… - Science, 2011 - science.org
Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf)
malaria in≥ 80% of recipients. Pf sporozoites (PfSPZ) administered by mosquito bites are …
malaria in≥ 80% of recipients. Pf sporozoites (PfSPZ) administered by mosquito bites are …
[HTML][HTML] Protection against Plasmodium falciparum malaria by PfSPZ Vaccine
JE Epstein, KM Paolino, TL Richie, M Sedegah… - JCI insight, 2017 - ncbi.nlm.nih.gov
BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ)
malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf …
malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf …
A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria
SB Sirima, A Ouédraogo, AB Tiono… - Science translational …, 2022 - science.org
A highly effective malaria vaccine remains elusive despite decades of research.
Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine), a metabolically active …
Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine), a metabolically active …
CD8 T cell responses to infectious pathogens
P Wong, EG Pamer - Annual review of immunology, 2003 - annualreviews.org
CD8 T cells respond to viral infections but also participate in defense against bacterial and
protozoal infections. In the last few years, as new methods to accurately quantify and …
protozoal infections. In the last few years, as new methods to accurately quantify and …
Immune effector mechanisms in malaria
K Marsh, S Kinyanjui - Parasite immunology, 2006 - Wiley Online Library
That humans in endemic areas become immune to malaria offers encouragement to the
idea of developing protective vaccines. However natural immunity is relatively inefficient …
idea of developing protective vaccines. However natural immunity is relatively inefficient …