Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …

Brugada syndrome (BrS) is an “inherited” condition characterized by predisposition to
syncope and cardiac arrest, predominantly during sleep. The prevalence is∼ 1: 2,000, and …

Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic
augmentation of CaV1. 2 voltage-gated calcium channels,,–. However, this augmentation …

Brugada syndrome (BrS) was first described as a primary electrical disorder predisposing to
the risk of sudden cardiac death and characterized by right precordial lead ST elevation …

The rapid development of genome editing technology has brought major breakthroughs in
the fields of life science and medicine. In recent years, the clustered regularly interspaced …

Summary Background Brugada syndrome (BrS) is a cardiac channelopathy that can result in
sudden cardiac death (SCD). SCN5A is the most frequent gene linked to BrS, but the …

Brugada syndrome (BrS) is a rare hereditary arrhythmia disorder, with a distinctive ECG
pattern, correlated with an increased risk of ventricular arrhythmias and sudden cardiac …

Abstract Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), poses an enormous challenge to the medical …

Abstract Aims Brugada syndrome (BrS) is characterized by a unique electrocardiogram
(ECG) pattern and life-threatening arrhythmias. However, the Type 1 Brugada ECG pattern …

Genetic variants play an important role in conferring risk for cardiovascular diseases (CVDs).
With the rapid development of next-generation sequencing (NGS), thousands of genetic …