Plants produce a diversity of plant secondary metabolites (PSMs), which function as defense
chemicals against herbivores and microorganisms but also as signal compounds. An …

Oxidative stress is a natural physiological process where the levels of oxidants, such as
reactive oxygen species (ROS) and nitrogen (RNS), exceed the strategy of antioxidant …

Actively dividing cells, including some cancers, rely on aerobic glycolysis rather than
oxidative phosphorylation to generate energy, a phenomenon termed the Warburg effect …

The potent environmental herbicide and weedicide paraquat is linked to neuromotor defects
and Parkinson's disease (PD). We have evaluated the neuroprotective role of citric acid …

The broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and
cancer, but its effect on healthspan and longevity are unclear. We used the C. elegans …

Virtually all age-related neurodegenerative diseases (NDs) can be characterized by the
accumulation of proteins inside and outside the cell that are thought to significantly …

Perfluorooctane sulfonate (PFOS) has been widely utilized in numerous industries. Due to
long environmental and biological half-lives, PFOS is a major public health concern …

Mild impairment of mitochondrial function has been shown to increase lifespan in genetic
model organisms including worms, flies and mice. To better understand the mechanisms …

The high substrate selectivity of the ubiquitin/proteasome system is mediated by a large
group of E3 ubiquitin ligases. The ubiquitin ligase CHIP regulates the degradation of …

Organisms are often exposed to fluctuating environments and changes in intracellular
homeostasis, which can have detrimental effects on their proteome and physiology. Thus …