The unique features of nanomaterials have led to their rapid development in the biomedical
field. In particular, functionalized nanoparticles (NPs) are extensively used in the delivery of …

Retroviral integration is catalysed by a tetramer of integrase (IN) assembled on viral DNA
ends in a stable complex, known as the intasome,. How the intasome interfaces with …

Gag proteins play an important role in many stages of the retroviral replication cycle. They
orchestrate viral assembly, interact with numerous host cell proteins, engage in regulation of …

The interactions between a retrovirus and host cell chromatin that underlie integration and
provirus expression are poorly understood. The prototype foamy virus (PFV) structural …

Titanium dioxide nanoparticles (TiO2 NPs) are widely used for industrial and commercial
applications. Once inside the body, they translocate into the bloodstream and reach different …

Foamy viruses (FV) belong to the genus Spumavirus, which forms a distinct lineage in the
Retroviridae family. Although the infection in natural hosts and zoonotic transmission to …

Simian foamy virus (SFV) is a ubiquitous retrovirus in nonhuman primates (NHPs) that can
be transmitted to humans, mostly through severe bites. In the past few years, our laboratory …

The adaptation of CRISPR/Cas technology for use in mammals has revolutionized genome
engineering. In particular with regard to clinical application, efficient expression of Cas9 …

Zoonotic simian foamy viruses (SFV) establish lifelong infection in their human hosts.
Despite repeated transmission of SFV from nonhuman primates to humans, neither …

Vector systems based on different retroviruses are widely used to achieve stable integration
and expression of transgenes. More recently, transient genetic manipulation systems were …