Summary β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has
historically focused on its actions as the β‐secretase responsible for the production of β …

The β-amyloid (Aβ) peptide is the major constituent of amyloid plaques in Alzheimer's
disease (AD) brain and is likely to play a central role in the pathogenesis of this devastating …

Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological
hallmark of Alzheimer's disease (AD). Aβ is generated from sequential cleavages of the β …

Alzheimer disease is characterized by the accumulation of abnormally folded protein
fragments, ie, amyloid beta peptide (Aβ) and tau that precipitate in amyloid plaques and …

The pathogenesis of Alzheimer's disease is highly complex. While several pathologies
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …

sorLA (sorting protein-related receptor) is a type-1 membrane protein of unknown function
that is expressed in neurons. Its homology to sorting receptors that shuttle between the …

Neuritic plaques in the brain are a major neuropathological hallmark of Alzheimer's disease.
They are formed by the deposition and aggregation of extracellular amyloid-β protein (Aβ) …

Alzheimer's disease (AD) is the most common form of dementia and associated with the
progressive accumulation of amyloid β-peptides (Aβ) in form of extracellular amyloid …

During the first 100 years of Alzheimer's disease research, this devastating and intractable
disorder has been characterized at the clinical, histological, and molecular levels …

Alzheimer's disease (AD) is characterized by progressive accumulation of misfolded
proteins, which form senile plaques and neurofibrillary tangles, and the release of …