Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of
acid-base homeostasis. However, in recent years the understanding of the function of the …

The epithelium of the kidney collecting duct (CD) is composed mainly of two different types
of cells with distinct and complementary functions. CD principal cells traditionally have been …

Background/Aims: Endothelial cell stiffness plays a key role in endothelium-dependent
control of vascular tone and arterial blood pressure. Actin polymerization and distribution of …

Abstract The C l−/HC O 3− exchanger pendrin (SLC26A4, PDS) is located on the apical
membrane of B-intercalated cells in the kidney cortical collecting duct and the connecting …

Pertussis disease, characterized by severe and prolonged coughing episodes, can progress
to a critical stage with pulmonary inflammation and death in young infants. However, there …

Abstract Pendrin (SLC26A4, PDS) is an electroneutral anion exchanger transporting I-, Cl-,
HCO3-, OH-, SCN-and formate. In the thyroid, pendrin is expressed at the apical membrane …

The transport of chloride and bicarbonate across epithelia controls the pH and volume of the
intracellular and luminal fluids, as well as the systemic pH and vascular volume. The anion …

SLC26A4 mutations can cause a distinctive hearing loss phenotype with sudden drops and
fluctuation in patients. Existing Slc26a4 mutant mouse lines have a profound loss of hearing …

The human gene SLC26A4 and the mouse ortholog Slc26a4 code for the protein pendrin,
which is an anion exchanger expressed in apical membranes of selected epithelia. In the …

The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be
limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also …