Iron and chelation in biochemistry and medicine: new approaches to controlling iron metabolism and treating related diseases

GJ Kontoghiorghes, CN Kontoghiorghe - Cells, 2020 - mdpi.com
Iron is essential for all living organisms. Many iron-containing proteins and metabolic
pathways play a key role in almost all cellular and physiological functions. The diversity of …

Coordination compounds in cancer: Past, present and perspectives

F Trudu, F Amato, P Vaňhara, T Pivetta… - Journal of applied …, 2015 - Elsevier
Metal-based coordination compounds have been used throughout the history of human
medicine to treat various diseases, including cancer. Since the discovery of cisplatin in …

Synthesis, characterization, crystal structure, DNA and HSA Interactions, and anticancer activity of a mononuclear Cu (II) complex with a Schiff base ligand containing …

SU Parsekar, K Paliwal, P Haldar, PKS Antharjanam… - ACS …, 2022 - ACS Publications
A mononuclear Cu (II) complex [Cu (HL)(o-phen)]· H2O (1)[H3L=, o-phen= 1, 10-
phenanthroline] was isolated from methanol, and its X-ray single-crystal structure was …

Impact of the halogen substitution pattern on the biological activity of organoruthenium 8-hydroxyquinoline anticancer agents

M Kubanik, H Holtkamp, T Sohnel… - …, 2015 - ACS Publications
8-Hydroxyquinoline and its derivatives have a broad variety of pharmacological properties,
which make them an ideal bioactive building block in the development of metal-based …

Synthesis, structure, DNA/protein binding, and anticancer activity of some half-sandwich cyclometalated Rh (III) and Ir (III) complexes

S Mukhopadhyay, RK Gupta, RP Paitandi… - …, 2015 - ACS Publications
The Schiff base ligands benzylidene (4-tert-butylphenyl) amine 4-methyl ester (L1),(4-
nitrobenzylidene)(4-tert-butylphenyl) amine (L2), and (4-cyanobenzylidene)(4-tert …

Evaluation of in vitro distribution and plasma protein binding of selected antiviral drugs (favipiravir, molnupiravir and imatinib) against SARS-CoV-2

O Dömötör, ÉA Enyedy - International Journal of Molecular Sciences, 2023 - mdpi.com
There are a number of uncertainties regarding plasma protein binding and blood distribution
of the active drugs favipiravir (FAVI), molnupiravir (MOLNU) and imatinib (IMA), which were …

Gallium (Ga)–strontium (Sr) layered double hydroxide composite coating on titanium substrates for enhanced osteogenic and antibacterial abilities

K Li, H Tian, A Guo, L Jin, W Chen… - Journal of Biomedical …, 2022 - Wiley Online Library
Bacterial infection and poor osteogenic capacity can result in the loosing or failure of
titanium (Ti)‐based implants in the clinic. Therefore, it is urgent to design an effective …

Binding mechanisms of half-sandwich Rh (III) and Ru (II) arene complexes on human serum albumin: A comparative study

O Dömötör, ÉA Enyedy - JBIC Journal of Biological Inorganic Chemistry, 2019 - Springer
Various half-sandwich ruthenium (II) arene complexes and rhodium (III) arene complexes
have been intensively investigated due to their prominent anticancer activity. The interaction …

New era in the treatment of iron deficiency anaemia using trimaltol iron and other lipophilic iron chelator complexes: historical perspectives of discovery and future …

GJ Kontoghiorghes, A Kolnagou, T Demetriou… - International Journal of …, 2021 - mdpi.com
The trimaltol iron complex (International Non-proprietary Name: ferric maltol) was originally
designed, synthesised, and screened in vitro and in vivo in 1980–1981 by Kontoghiorghes …

Protein binding studies with human serum albumin, molecular docking and in vitro cytotoxicity studies using HeLa cervical carcinoma cells of Cu (II)/Zn (II) complexes …

SU Parsekar, P Velankanni, S Sridhar, P Haldar… - Dalton …, 2020 - pubs.rsc.org
The interaction of two binuclear mixed ligand Cu (II) complexes [Cu (o-phen) LCu (OAc)](1)
and [Cu (o-phen) LCu (o-phen)](OAc)(2)(H3L= o-HOC6H4C (H) N–NH–C (OH) N–NC (H) …