The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics
on the market in Europe after 2013. In that context, the European Commission invited …

Predicting human safety risks of novel xenobiotics remains a major challenge, partly due to
the limited availability of human cells to evaluate tissue-specific toxicity. Recent progress in …

To anticipate to increased testing needs for reproductive toxicity and 3R approaches, we
studied zebrafish embryo/larva as an alternative for animal testing for developmental toxicity …

A comprehensive review of recent scientific evidence examining the contributions of animal
experimentation to human healthcare. The book also explores toxicity prediction, animal use …

The assumption that animal models are reasonably predictive of human outcomes provides
the basis for their widespread use in toxicity testing and in biomedical research aimed at …

The increasing demands on toxicology of large-scale risk assessment programmes for
chemicals and emerging or expanding areas of chemical use suggest it is timely to review …

Widespread reliance on animal models during preclinical research and toxicity testing
assumes their reasonable predictivity for human outcomes. However, of 20 published …

A consortium of biopharmaceutical companies previously developed an optimized Zebrafish
developmental toxicity assay (ZEDTA) where chorionated embryos were exposed to non …

A biological system is more than the sum of its parts–it accomplishes many functions via
synergy. Deconstructing the system down to the molecular mechanism level necessitates …

Recent publications describe the development of in vitro models of human development, for
which applications in developmental toxicity testing can be envisaged. To date, these …