Data on long-distance enhancer-mediated activation of gene promoters and complex
regulation of gene expression by multiple enhancers have prompted the hypothesis that the …

Insulators play a central role in subdividing the chromosome into a series of discrete
topologically independent domains and in ensuring that enhancers and silencers contact …

The chromosomes of multicellular animals are organized into a series of topologically
independent looped domains. This domain organization is critical for the proper utilization …

Recent findings provide evidence that tDNAs function as chromatin insulators from yeast to
humans. TFIIIC, a transcription factor that interacts with the B-box in tDNAs as well as …

Chromatin insulators block the action of transcriptional enhancers when interposed between
an enhancer and a promoter. In this study, we examined the role of chromatin loops formed …

The mechanisms underlying long-range interactions between chromatin regions and the
principles of chromosomal architecture formation are currently under extensive scrutiny. A …

Boundary elements or insulators subdivide eukaryotic chromosomes into a series of
structurally and functionally autonomous domains. They ensure that the action of enhancers …

Transvection is a phenomenon of interallelic communication whereby enhancers of one
allele can activate a promoter located on the homologous chromosome. It has been shown …

The Su (Hw) protein was first identified as a DNA-binding component of an insulator
complex in Drosophila. Insulators are regulatory elements that can block the enhancer …

Механизмы дистанционных взаимодействий между участками хроматина и принципы
формирования хромосомной архитектуры в настоящее время активно исследуются. В …