Post-stroke depression: mechanisms and pharmacological treatment

RF Villa, F Ferrari, A Moretti - Pharmacology & therapeutics, 2018 - Elsevier
Depression, the most frequent psychiatric disorder following ischaemic stroke, negatively
affects survivals' functional outcome, response to rehabilitation and quality of life …

Insulin resistance and oxidative stress in the brain: what's new?

M Maciejczyk, E Żebrowska, A Chabowski - International journal of …, 2019 - mdpi.com
The latest studies have indicated a strong relationship between systemic insulin resistance
(IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment …

The neurobiology of depression: an integrated overview from biological theories to clinical evidence

F Ferrari, RF Villa - Molecular neurobiology, 2017 - Springer
Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …

Molecular aspects of depression: a review from neurobiology to treatment

GRV Boas, RB de Lacerda, MM Paes, P Gubert… - European journal of …, 2019 - Elsevier
Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …

Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives

F Ferrari, A Moretti, RF Villa - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent
neurodegenerative disorders. Despite their pathophysiological and clinical differences, they …

Redox balance, antioxidant defense, and oxidative damage in the hypothalamus and cerebral cortex of rats with high fat diet‐induced insulin resistance

M Maciejczyk, E Żebrowska, A Zalewska… - Oxidative medicine …, 2018 - Wiley Online Library
Oxidative stress is a key pathogenic factor in both neurogenerative and metabolic diseases.
However, its contribution in the brain complications of insulin resistance is still not well …

Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction

CL Howerton, TL Bale - Proceedings of the National …, 2014 - National Acad Sciences
Maternal stress is a key risk factor in neurodevelopmental disorders, which often have a sex
bias in severity and prevalence. We previously identified O-GlcNAc transferase (OGT) as a …

A comprehensive review on bioavailability, safety and antidepressant potential of natural bioactive components from tea

J Shao, Y Wei, X Wei - Food Research International, 2022 - Elsevier
Depression is a global public health issue with high morbidity and mortality, which tends to
cause fatigue, inability to concentrate, insomnia, and loss of appetite, especially represented …

High protein diet induces oxidative stress in rat cerebral cortex and hypothalamus

E Żebrowska, M Maciejczyk… - International journal of …, 2019 - mdpi.com
This is the first study to analyze the impact of high protein diet (HPD) on antioxidant defense,
redox status, as well as oxidative damage on both a local and systemic level. Male Wistar …

Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging

S Lores-Arnaiz, P Lombardi, AG Karadayian… - Neurochemical …, 2016 - Springer
Alterations in mitochondrial bioenergetics have been associated with brain aging. In order to
evaluate the susceptibility of brain cortex synaptosomes and non-synaptic mitochondria to …