Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis
Protein aggregation is common to dozens of diseases including prionoses, diabetes,
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …
GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two …
cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two …
TDP-43-regulated cryptic RNAs accumulate in Alzheimer's disease brains
V Estades Ayuso, S Pickles, T Todd, M Yue… - Molecular …, 2023 - Springer
Abstract Background Inclusions of TAR DNA-binding protein 43 kDa (TDP-43) has been
designated limbic-predominant, age-related TDP-43 encephalopathy (LATE), with or without …
designated limbic-predominant, age-related TDP-43 encephalopathy (LATE), with or without …
[HTML][HTML] Exercise, redox system and neurodegenerative diseases
Regular exercise induces a wide range of redox system-associated molecular adaptive
responses to the nervous system. The intermittent induction of reactive oxygen species …
responses to the nervous system. The intermittent induction of reactive oxygen species …
The role of Kv7. 2 in neurodevelopment: insights and gaps in our understanding
N Dirkx, F Miceli, M Taglialatela… - Frontiers in …, 2020 - frontiersin.org
Kv7. 2 subunits encoded by the KCNQ2 gene constitute a critical molecular component of
the M-current, a subthreshold voltage-gated potassium current controlling neuronal …
the M-current, a subthreshold voltage-gated potassium current controlling neuronal …
Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer's disease
Given the complex heterogeneity of pathological changes occurring in Alzheimer's disease
(AD), any therapeutic effort absolutely requires a multi-targeted approach, because attempts …
(AD), any therapeutic effort absolutely requires a multi-targeted approach, because attempts …
Systematic characterization of a non-transgenic Aβ1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice
R Jiménez-Herrera, A Contreras, S Djebari… - Biology of sex …, 2023 - Springer
Background The amyloid-β (A β) cascade is one of the most studied theories linked to AD. In
multiple models, A β accumulation and dyshomeostasis have shown a key role in AD onset …
multiple models, A β accumulation and dyshomeostasis have shown a key role in AD onset …
Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer's disease: An update
With more than 80 subunits, potassium (K+) channels represent a group of ion channels
showing high degree of diversity and ubiquity. They play important role in the control of …
showing high degree of diversity and ubiquity. They play important role in the control of …
Chemical modulation of Kv7 potassium channels
The rising interest in Kv7 modulators originates from their ability to evoke fundamental
electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic …
electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic …
Amyloid-β(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus
J Mayordomo-Cava, J Yajeya, JD Navarro-Lopez… - PLoS …, 2015 - journals.plos.org
During early stages of Alzheimer's disease (AD), synaptic dysfunction induced by toxic
amyloid-β (A β) is present before the accumulation of histopathological hallmarks of the …
amyloid-β (A β) is present before the accumulation of histopathological hallmarks of the …