血管内皮细胞和内皮细胞释放的活性因子是调控血管舒张功能的重要因素. 糖尿病是慢性心血管
疾病的高危因素之一. 目前认为高糖和糖尿病引起的内皮细胞功能障碍是造成血管功能改变 …

Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic
signaling molecule involved in cardiovascular and metabolic regulation. More recently, an …

Inorganic nitrate (NO3−), nitrite (NO2−) and NO are nitrogenous species with a diverse and
interconnected chemical biology. The formation of NO from nitrate and nitrite via a reductive …

In patients with diabetes mellitus, the ability of ischemic tissue to synchronize the molecular
and cellular events leading to restoration of tissue perfusion in response to the …

Inorganic nitrite, a metabolite of endogenously produced nitric oxide (NO) from NO
synthases (NOS), provides the largest endocrine source of directly bioavailable NO. The …

The discovery of nitric oxide and its role in almost every facet of human biology opened a
new avenue for treatment through manipulation of its canonical signaling and by attempts to …

Nitric oxide (NO) and hydrogen sulfide (H 2 S) are two gasotransmitters that are produced in
the human body and have a key role in many of the physiological activities of the various …

Ischemic vascular remodeling occurs in response to stenosis or arterial occlusion leading to
a change in blood flow and tissue perfusion. Altered blood flow elicits a cascade of …

Objective Consumption of a high-fat/high-fructose Western diet (WD) is linked to rising
obesity and heart disease, particularly diastolic dysfunction which characterizes early …

Wound therapy remains a clinical challenge due to the complexity of healing pathology and
high demand of achieving functional and aesthetically satisfactory scars. Newly formed …